ReviewLasers in medical science2020
ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases-an integrative literature review.
Review in Lasers in medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Clinical applications and molecular mechanisms for intravenous laser blood irradiation: a systematic review.Lasers in medical science · 2025Pooled it
- Photobiomodulation in the management of persistent olfactory and gustatory dysfunction post-COVID-19: a systematic review.Lasers in medical science · 2025Pooled it
- Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review.Lasers in medical science · 2024Pooled it
- Effects of the invasive and non-invasive systemic photobiomodulation using low-level laser in experimental models: A systematic review.Lasers in medical science · 2023Pooled it
- Effects of ILIB on anxiety and physiological parameters during third molar surgery: a pilot randomized trial.Lasers in medical science · 2025Trial
- Evaluation of local and systemic photobiomodulation in only single-implant insertion: a randomized clinical trial.Oral and maxillofacial surgery · 2025Trial
- Evaluation of vascular photobiomodulation for orofacial pain and tension type headache following COVID 19 in a pragmatic randomized clinical trial.Scientific reports · 2024Trial
- The Effect of Intravascular Laser Irradiation of Blood on Serum Biomarkers and Clinical Outcome in Knee Osteoarthritis Patients: A Double-Blind Randomized Control Trial.International journal of molecular sciences · 2024Trial
- Efficacy of ILIB on periodontal clinical parameters and glycemic control in patients with periodontitis and type II diabetes-randomized clinical trial.Lasers in medical science · 2022Trial
- Potential Effect of Intravascular Laser Irradiation of Blood (ILIB) in Improving Physical Performance: A Narrative Review.Journal of functional morphology and kinesiology · 2025Review
- Combined aerobic exercise and photobiomodulation for pain and other symptoms in fibromyalgia: study protocol.Pain management · 2025Article
- Photobiomodulation on vocal training and rehabilitation: Delphi consensus based on experts.CoDAS · 2025Article
- Combination of Different Laser Wavelengths as a Treatment Strategy for Maxillary Osteonecrosis: A Case Report.Journal of lasers in medical sciences · 2025Article
- Transcutaneous intravascular laser irradiation of blood affects plasma metabolites of women.Scientific reports · 2024Article
- Intravascular Laser Blood Irradiation (ILIB) Enhances Antioxidant Activity and Energy Metabolism in Aging Ovaries.Journal of personalized medicine · 2024Article
- Analysis of modified ilib therapy in patients submitted to plastic surgery.Lasers in medical science · 2024Article
- Intravascular laser irradiation of blood as novel migraine treatment: an observational study.European journal of medical research · 2023Observational
- Effects of intravascular photobiomodulation on cognitive impairment and crossed cerebellar diaschisis in patients with traumatic brain injury: a longitudinal study.Lasers in medical science · 2023Article
- Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review.Lasers in medical science · 2023Review
- Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review.Lasers in medical science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To perform an integrative review of the literature on the effectiveness of intravascular laser irradiation of blood (ILIB) as an adjunct therapy in the treatment of chronic systemic diseases. This is an integrative literature review that included non-randomized and randomized controlled clinical trials that specifically evaluated the therapeutic effect of ILIB on chronic systemic diseases, without restriction of time, and written in English. The Medical Publications (PubMed)/MEDLINE database was used. MeSH (Medical Subject Headings) was used to select search descriptors with the Boolean operators "AND/OR." After applying the inclusion and exclusion criteria, 13 articles were selected. Coronary diseases were the most prevalent, followed by type 2 diabetes mellitus, with the coronary artery being the most widely used access route for ILIB application. Despite the varied parameters and protocols for using this kind of therapy, all studies have shown satisfactory results in the patients' clinical condition. ILIB proved to be effective in all organic systems, showing some positive result. However, studies on the effect of this therapy on various diseases are still scarce in the literature, and there is a need for more well-designed clinical trials to better understand the role of ILIB in various systemic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.