Evidence map›Paper›PMID 32656675›Full record

ArticleClinical and experimental medicine2020

Analysis of pathological changes and related factors in liver tissue of HBeAg-negative patients with low HBsAg levels.

Li Liu, Chunyun Liu, Junyi Li, Yingrong Du, Jie Chen, Hui Wang, Huimin Li, Lixian Chang

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Li LiuDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China. liuli197210@163.com.ORCID http://orcid.org/0000-0001-7712-4931
Chunyun LiuDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Junyi LiDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Yingrong DuDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Jie ChenDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Hui WangDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Huimin LiDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Lixian ChangDepartment of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.
Kunming Third People's Hospital · CN

Funding

Yunnan Provincial Science and Technology Department Applied Basic Research Project 2017FH001-088
6 · The paper itself

Abstract

The relationship between pathological changes in liver tissue and the level of hepatitis B surface antigen (HBsAg) remains unclear. This study aimed to analyze the pathological changes in liver tissue and its related factors in patients with low-level HBsAg in order to provide a basis for judging the condition of these patients. A retrospective study was performed on 96 chronic hepatitis B patients with HBsAg levels < 1400 IU/ml and > 0.05 IU/ml. The histopathological examination of these patients was conducted. Univariate and multivariate analyses were used to determine risk factors for pathological changes. Among the 96 patients, 57.3% (55) had inflammatory events ≥ G2 and 33.4% (33) had fibrosis ≥ S2. HBV infection duration (p = 0.001) and splenic vein diameter (p = 0.001) were independent risk factors of liver inflammation (≥ G2) in patients with low-level HBsAg, while AST (p = 0.006) and PLT (p = 0.005) were independent risk factors of liver fibrosis (≥ S2). Moreover, HBV infection duration (p < 0.001) and spleen vein (p = 0.001) were independent factors of potential antiviral treatment. Liver inflammation and fibrosis are still common in patients with low-level HBsAg; thus, the monitoring and appropriate antiviral treatment cannot be ignored.

Indexed as

AdolescentAdultAntiviral AgentsFemaleHepatitis B, ChronicHepatitis B e AntigensHepatitis B Surface AntigensHumansLiverLiver CirrhosisLogistic ModelsMaleMiddle AgedRetrospective StudiesTime FactorsYoung AdultAntiviral AgentsHepatitis B e AntigensHepatitis B Surface AntigensFibrosis stagingInflammation gradeLiver histopathologyLow levels of HBsAgRelated factors

Identifiers

PMID32656675
OpenAlexW3041879659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.