Evidence map›Paper›PMID 32656660›Full record

ArticleChild psychiatry and human development2020

A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity.

Gregory L Hanna, Yanni Liu, Haley E Rough, Mihir Surapaneni, Barbara S Hanna, Paul D Arnold, William J Gehring

Open access · greenAbstract read
In one paragraph

Article in Child psychiatry and human development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Exploring the role of post-error processing in social anxiety across age.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  8. Article
  9. Article
  10. Brain response to errors in children who stutter.Journal of fluency disorders · 2024
    Article
  11. Article
  12. Article
  13. Neural indices of performance monitoring are associated with daily emotional functioning in youth with anxiety disorders: An ERP and EMA study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gregory L HannaDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA. ghanna@med.umich.edu.ORCID 0000-0002-0742-6990
Yanni LiuDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.
Haley E RoughDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.
Mihir SurapaneniDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.
Barbara S HannaDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.
Paul D ArnoldMathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, T2N 4N1, Canada.
William J GehringDepartment of Psychology, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109-5766, USA.
University of Michigan · USUniversity of Calgary · CA

Funding

2/3 Brain Function and Genetics in Pediatric Obsessive-Compulsive BehaviorsR01MH085321 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANNA, GREGORY L. · 2009 to 2019
$2.9M
Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive BehaviorR01MH101493 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARNOLD, PAUL DANIEL, GEHRING, WILLIAM J · 2013 to 2016
$2.3M
NIMH NIH HHS R01 MH085321NIMH NIH HHS R01 MH101493
6 · The paper itself

Abstract

The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ages 8 to 18 years. Forty-one cases had generalized anxiety disorder (GAD); 55 cases had other anxiety disorders (OAD) without GAD. ERN amplitude was significantly increased in AD cases compared to HC. The area under the curve (AUC) in the ROC analysis was 0.64, indicating the ERN is an inadequate diagnostic test for AD altogether. The ERN was significantly increased in cases with either GAD or OAD compared to HC. The AUC in ROC analyses with GAD and OAD was 0.75 and 0.56, respectively, suggesting the ERN provides an adequate diagnostic test for GAD but not for OAD.

Indexed as

AdolescentAnxiety DisordersBiomarkersChildElectroencephalographyEvoked PotentialsFemaleHumansMaleBiomarkersAnxietyBiomarkerDiagnosisError-related negativityPediatricReceiver operating characteristic analysis

Identifiers

PMID32656660
PMCPMC7529976
OpenAlexW3041569606

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.