Evidence map›Paper›PMID 32656604›Full record

ArticleDigestive diseases and sciences2021

Superiority of Higher-Volume Fresh Feces Compared to Lower-Volume Frozen Feces in Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Colitis.

Amol Agarwal, Anurag Maheshwari, Sandeep Verma, Denise Arrup, Laila Phillips, Rakesh Vinayek, Padmanabhan Nair, Matilda Hagan, Sudhir Dutta

Abstract readComparative StudyMulticenter Study
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In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Amol AgarwalMercy Medical Center, 301 St Paul Pl, Physician's Office Building, 7th Floor, Baltimore, MD, 21202, USA.
Anurag MaheshwariMercy Medical Center, 301 St Paul Pl, Physician's Office Building, 7th Floor, Baltimore, MD, 21202, USA. amahesha@mdmercy.com.
Sandeep VermaSinai Hospital of Baltimore, Baltimore, MD, USA.
Denise ArrupSinai Hospital of Baltimore, Baltimore, MD, USA.
Laila PhillipsSinai Hospital of Baltimore, Baltimore, MD, USA.
Rakesh VinayekSinai Hospital of Baltimore, Baltimore, MD, USA.
Padmanabhan NairSinai Hospital of Baltimore, Baltimore, MD, USA.
Matilda HaganMercy Medical Center, 301 St Paul Pl, Physician's Office Building, 7th Floor, Baltimore, MD, 21202, USA.
Sudhir DuttaSinai Hospital of Baltimore, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

goalsTo compare the clinical outcomes of different protocols for fecal microbiota transplantation (FMT) in two community hospitals with similar patient demographics.

backgroundFMT is commonly performed for recurrent or refractory Clostridioides difficile infection (rCDI). The clinical efficacy of FMT for this indication has been well established. However, there has been no standardization or optimization of the amount of fecal material, method of feces preparation, or route of delivery for FMT. STUDY: In this retrospective study, patients with rCDI received FMT using commercially available frozen fecal preparation (22.7 g) at Center A and locally prepared fresh fecal filtrate (30-50 g) at Center B. The primary outcome was defined as complete resolution of clinical symptoms related to rCDI after at least 8 weeks of follow-up.

resultsFifty patients from each center were included in the study. Clinical success after initial FMT with lower-volume frozen fecal preparation at Center A was 32/50 (64.0%) compared to 49/50 (98.0%) with higher-volume fresh fecal filtrate at Center B (p < 0.0001). Seventeen patients in Center A and 1 patient in Center B underwent at least one repeat FMT. Overall clinical success was achieved in 43/50 (86%) of patients in Center A and 50/50 (100%) in Center B (p = 0.012).

conclusionsOur results suggest superior clinical efficacy of a larger amount of fresh fecal filtrate over a smaller amount of commercially available frozen fecal preparation. Further studies are needed to examine the effect of varying amounts of feces and the optimal protocol for FMT in patients with rCDI.

Indexed as

FreezingAgedClostridium InfectionsColitisFecal Microbiota TransplantationFemaleHumansLiving DonorsMaleMiddle AgedRecurrenceRetrospective StudiesC. difficile infectionFecal microbiota transplantationFeces

Identifiers

PMID32656604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.