Evidence map›Paper›PMID 32656595›Full record

ArticleClinical oral investigations2021

Localisation of citrullinated and carbamylated proteins in inflamed gingival tissues from rheumatoid arthritis patients.

Yin Hui Lee, Nor Adinar Baharuddin, Siew Wui Chan, Mohammad Tariqur Rahman, P Mark Bartold, Sargunan Sockalingam, Rathna Devi Vaithilingam

Registry-linked trialAbstract read
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In one paragraph

Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05880303 (Effect of Nonsurgical Periodontal Therapy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05880303 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Nonsurgical Periodontal Therapy (NSPT) on Inflammatory Mediators, Subgingival Microbiota and Quality of Life Impacts in Rheumatoid Arthritis Subjects With Periodontitis

TypeinterventionalSponsorUniversity of MalayaRan2023 to 2025Enrolled20ConditionsPeriodontitis, Rheumatoid ArthritisArmsNonsurgical periodontal therapy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Neutrophils in Inflammatory Bone Diseases.Current osteoporosis reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yin Hui LeeDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Nor Adinar BaharuddinDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Siew Wui ChanDepartment of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Mohammad Tariqur RahmanFaculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
P Mark BartoldDepartment of Dentistry, University of Adelaide, Adelaide, Australia.
Sargunan SockalingamDepartment of Rheumatology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Rathna Devi VaithilingamDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia. rathna@um.edu.my.ORCID http://orcid.org/0000-0002-0479-5141
University of Malaya · MYThe University of Adelaide · AU

Funding

Dental Postgraduate Research Grant University Malaya DPRG/27/17Frontier Research Grant University Malaya FG040-17AFR
6 · The paper itself

Abstract

objectivesIt has been proposed that citrullination and carbamylation occur in the inflamed periodontium and could be the plausible mechanisms for the generation of antigens involved in the development and progression of RA. The purpose of this study was to determine the presence and location of citrullinated and carbamylated proteins in the gingival tissues and compare their abundance in periodontitis (PD) patients with or without RA. MATERIALS AND

methodsGingival tissue samples of healthy (n = 5), PD with RA (n = 5) and PD without RA (n = 5) were collected. Specimens were formalin fixed, paraffin embedded and sectioned at 4 μm. The tissue sections were analysed for the presence of citrullinated and carbamylated proteins by immunohistochemistry. Semi-quantitative analysis was performed to quantify and compare the protein abundance between groups.

resultsThe number of cells containing citrullinated and carbamylated proteins with higher intensity was markedly increased in gingival tissues from PD with or without RA in comparison with healthy controls.

conclusionInflamed gingival tissue is a potential source of citrullinated and carbamylated proteins other than synovial tissues. The extent to which the local accumulation of these proteins contributes to the pathogenesis of RA needs further elucidation. CLINICAL RELEVANCE: If PD is a potential source of post-translationally modified proteins, untreated PD should not be taken lightly in the context of RA. Hence, addressing gingival inflammation should be viewed as an important preventive measure in the general population not only for the progression of periodontal disease but also reducing the risk of developing extra-oral comorbidities.

Indexed as

Arthritis, RheumatoidPeriodontitisAutoantibodiesCitrullinationGingivaHumansPeriodontiumAutoantibodiesCarbamylationCitrullinationImmunohistochemistryPeriodontitisRheumatoid arthritis

Identifiers

PMID32656595
OpenAlexW3042050456

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.