Evidence map›Paper›PMID 32656537›Full record

ArticleNeurobiology of language (Cambridge, Mass.)2020

Use of longitudinal EEG measures in estimating language development in infants with and without familial risk for autism spectrum disorder.

Carol L Wilkinson, Laurel J Gabard-Durnam, Kush Kapur, Helen Tager-Flusberg, April R Levin, Charles A Nelson

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Neurobiology of language (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04598438 (Music to Enhance Auditory Encoding in Young Children), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04598438 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Music to Enhance Auditory Encoding in Young Children: A Pilot Study

TypeinterventionalSponsorChinese University of Hong KongRan2021 to 2025Enrolled48ConditionsHealthyArmsMusic behavioral early intervention program, Arts and crafts early enhancement program
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carol L WilkinsonDivision of Developmental Medicine, Boston Children's Hospital, 1 Autumn Street, 6th Floor, Boston, MA 02115.
Laurel J Gabard-DurnamDivision of Developmental Medicine, Boston Children's Hospital.
Kush KapurDepartment of Neurology, Boston Children's Hospital.
Helen Tager-FlusbergDepartment of Psychological and Brain Sciences, Boston University.
April R LevinDepartment of Neurology, Boston Children's Hospital.
Charles A NelsonDivision of Developmental Medicine, Boston Children's Hospital.
Boston Children's Hospital · USBoston University · US

Funding

Neurobehavioral Research on Infants at Risk for SLI and AutismR01DC010290 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, CHARLES ALEXANDER, TAGER-FLUSBERG, HELEN · 2009 to 2020
$7.5M
Translational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6M
Infants at Risk for Autism Spectrum Disorders or Language DelayR21DC008637 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TAGER-FLUSBERG, HELEN B. · 2006 to 2007
$439k
NIDCD NIH HHS R01 DC010290NIDCD NIH HHS R21 DC008637NIMH NIH HHS T32 MH112510
6 · The paper itself

Abstract

Language development in children with autism spectrum disorder (ASD) varies greatly among affected individuals and is a strong predictor of later outcomes. Younger siblings of children with ASD have increased risk of ASD, but also language delay. Identifying neural markers of language outcomes in infant siblings could facilitate earlier intervention and improved outcomes. This study aimed to determine whether EEG measures from the first 2-years of life can explain heterogeneity in language development in children at low- and high-risk for ASD, and to determine whether associations between EEG measures and language development are different depending on ASD risk status or later ASD diagnosis. In this prospective longitudinal study EEG measures collected between 3-24 months were used in a multivariate linear regression model to estimate participants' 24-month language development. Individual baseline longitudinal EEG measures included (1) the slope of EEG power across 3-12 months or 3-24 months of life for 6 canonical frequency bands, (2) estimated EEG power at age 6-months for the same frequency bands, and (3) terms representing the interaction between ASD risk status and EEG power measures. Modeled 24-month language scores using EEG data from either the first 2-years (Pearson R = 0.70, 95% CI 0.595-0.783,

Identifiers

PMID32656537
PMCPMC7351149
OpenAlexW2982501127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.