Evidence map›Paper›PMID 32656395›Full record

ReviewACS omega2020

Enzyme-Instructed Self-Assembly for Subcellular Targeting.

Shuang Liu, Bing Xu

Abstract readReview
In one paragraph

Review in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shuang LiuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
NCI NIH HHS R01 CA142746
6 · The paper itself

Abstract

Subcellular compartmentalization is a key feature of eukaryotic cells. Selectively targeting subcellular compartments, though holding many exciting opportunities for biomedicine, remains rather underdeveloped. Self-assembly provides a new way for subcellular targeting. In this mini-review, we briefly introduce the development of supramolecular self-assemblies for targeting the nucleus, mitochondria, endoplasmic reticulum, and cell membranes. We mainly focus on the use of enzyme-instructed self-assembly (EISA), which spatiotemporally controls the formation of supramolecular assemblies for subcellular targeting and its applications, such as developing cancer therapeutics.

Identifiers

PMID32656395
PMCPMC7345418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.