ArticleAmerican journal of translational research2020
Identifying drug candidates for hepatocellular carcinoma based on differentially expressed genes.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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1 citing paper in PubMed, 2 citations in OpenAlex.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognosis for patients with advanced hepatocellular carcinoma (HCC) is extremely poor, mainly due to rapid progression and a paucity of effective drugs. Genome-wide analysis allows for potential drugs to be explored based on differentially expressed genes (DEGs). However, drug candidates and DEGs in HCC are largely unknown. In this study, we investigated DEGs and prognostication using The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC), the Gene Expression Omnibus (GEO), and immunohistochemical staining. Protein-protein interaction networks between DEGs were also analyzed to clarify 12 hub genes and query online databases for potential HCC therapeutic drugs. We found that 885 of 3219 DEGs from a TCGA dataset were associated with prognosis. We clarified 12 hub genes that were overexpressed in tumor samples and significantly associated with poor overall survival (OS) in HCC patients. These findings were validated using GEO and ICGC cohorts. Moreover, promising drug candidates targeted against HCC were predicted using online databases. Collectively, the upregulation of 12 hub genes was associated with poor prognosis for patients with HCC, and focusing on their expression may advance efforts towards targeted HCC therapies.
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Identifiers
32655798PMC7344051W3042957368What OpenQuestion holds
Registered trials
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