ArticleAmerican journal of translational research2020
Allogeneic fibroblast sheets accelerate cutaneous wound healing equivalent to autologous fibroblast sheets in mice.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Low-dose ionizing radiationMaterials today. Bio · 2025Article
- Anastomotic leakage prevention using dry-preserved fibroblast cell sheets in esophageal reconstruction.Regenerative therapy · 2025Article
- Pilot study of autologous multilayered fibroblast sheet transplantation for reinforcing bronchial stump healing after pulmonary lobectomy in a canine model.General thoracic and cardiovascular surgery · 2025Article
- Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025Article
- Scaffold-free 3D culture systems for stem cell-based tissue regeneration.APL bioengineering · 2024Review
- Establishment and characterization of multilayered fibroblast cell sheets from the canine oral mucosa, skin, and tail skin.Open veterinary journal · 2024Article
- Cellular therapeutics and immunotherapies in wound healing - on the pulse of time?Military Medical Research · 2024Review
- Fibroblasts are the most suitable cell source for regenerative medicine due to their high intracellular fibroblast growth factor 2 content.Biochemistry and biophysics reports · 2023Article
- Allogenic multilayered fibroblast sheets promote anastomotic site healing in a rat model of esophageal reconstruction.American journal of translational research · 2023Article
- Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing.Scientific reports · 2022Article
- Cryopreserved allogenic fibroblast sheets: development of a promising treatment for refractory skin ulcers.American journal of translational research · 2022Article
- Freezing of cell sheets using a 3D freezer produces high cell viability after thawing.Biochemistry and biophysics reports · 2021Article
- A pilot study using cell-mixed sheets of autologous fibroblast cells and peripheral blood mononuclear cells to treat refractory cutaneous ulcers.American journal of translational research · 2021Article
- Tissue repair and donor-dependent immune responses after allogeneic skeletal muscle-derived cell sheet transplantation in a rat gastric ulcer model.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThis study sought to confirm the difference of the wound-healing effect, cell survival, and immune response between autologous fibroblast sheets and allogeneic fibroblast sheets.
methodsRegarding wound healing, autologous or allogeneic fibroblast sheets were transplanted onto a mouse cutaneous wound healing model and the wound contraction rate was evaluated. The luciferase-expressing fibroblast sheet was prepared and the survival of the cell sheet was evaluated by IVIS
resultsAllogeneic fibroblast-sheet transplantation showed significant wound contraction at the early phase of wound healing, which was equivalent to that seen with the autologous fibroblast sheets. Luminescence of the autologous and allogeneic luciferase-expressing fibroblast sheets peaked on Day 5, and no luminescence was observed on Day 13. In the allogeneic fibroblast-sheet transplant group, a significant accumulation of immune cells was observed in the healed tissue but not in the early stage of wound healing.
conclusionThe allogeneic fibroblast sheets showed comparable rates of cell survival and wound-healing effects to those of the autologous fibroblast sheets, despite the subsequent immunogenic response. This result supports the potential practical clinical application of scaffold-free allogeneic fibroblast sheets based on the paracrine effect.
Indexed as
Identifiers
32655797PMC7344096W3043467166What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.