ArticleAmerican journal of translational research2020
LncRNA LINC00265/miR-485-5p/IRF2-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- LINC00265 Serves as a Diagnostic and Prognostic Marker for Acute Ischemic Stroke and INHIBITS Disease Progression Through the miR- 155 - 5p/TRIM32 Axis.Molecular neurobiology · 2025Article
- Navigating the Landscape of Exosomal microRNAs: Charting Their Pivotal Role as Biomarkers in Hematological Malignancies.Non-coding RNA · 2025Review
- The Preconditioning with Sevoflurane Alleviates Hypoxia-Reoxygenation-Induced Myocardial Cell Injury by Regulating the lncRNA LINC00265/miR-370-3p Axis.Cardiovascular toxicology · 2025Article
- Role of MicroRNAs in Acute Myeloid Leukemia.Genes · 2025Review
- InfoScan: A New Transcript Identification Tool Based on scRNA-Seq and Its Application in Glioblastoma.International journal of molecular sciences · 2025Article
- Article
- Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management.Journal of biomedical science · 2024Review
- Silencing of the long non-coding RNAOncology research · 2024Article
- Review
- The dual role of autophagy in acute myeloid leukemia.Journal of hematology & oncology · 2022Review
- Article
- Downregulation of circular RNA circ-HN1 suppressed the progression of gastric cancer through the miR-485-5p/GSK3A pathway.Bioengineered · 2022Article
- Circulating plasma exosomal long non-coding RNAs LINC00265, LINC00467, UCA1, and SNHG1 as biomarkers for diagnosis and treatment monitoring of acute myeloid leukemia.Frontiers in oncology · 2022Article
- LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Long Intergenic Noncoding RNA00265 Enhances Cell Viability and MetastasisFrontiers in oncology · 2022Article
- LINC00265/miR-4500 Axis Accelerates Acute Lymphoblastic Leukemia Progression by Enhancing STAT3 Signals.Cancer management and research · 2021Article
- miR-485-5p alleviates Alzheimer's disease progression by targeting PACS1.Translational neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtensive studies have shown that long non-coding RNAs (lncRNAs) play important roles in multiple cancers. The present study aimed to investigate the role and mechanism of lncRNA LINC00265 in the regulation of apoptosis in acute myeloid leukemia (AML) cells.
methodsGain- or loss-of-function experiments were conducted in AML cells to explore the effect of LINC00265 on AML. Autophagy was assessed by examining levels of Beclin-1, p62, and ratio of LC3-II/LC3-I. Cell proliferation and apoptosis of AML cells were evaluated by CCK-8 assay and flow cytometry, respectively. RNA pull-down was performed to enrich miR-485-5p interacted with LINC00265. The interaction between miR-485-5p and IRF2 3'UTR was analyzed by luciferase reporter assay.
resultsLINC00265 expression was significantly up-regulated, whereas miR-485-5p was down-regulated in serum of AML patients and AML cell lines. LINC00265 promoted, whereas miR-485-5p suppressed autophagy in AML cells. Mechanistically, LINC00265 functioned as a ceRNA for miR-485-5p to facilitate IRF2 expression. More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.
conclusionLINC00265 attenuates AML cell apoptosis by inducing autophagy via miR-485/IRF2 axis.
Indexed as
Identifiers
32655783PMC7344095W3042549089What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.