ReviewAmerican journal of translational research2020
Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia.
Review in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction.Journal of medicinal chemistry · 2026Article
- Cross-link Between CircRNAs and Neuroinflammation in Parkinson's Disease.Molecular neurobiology · 2026Review
- Indole-Derived Compounds as Redox-Modulators: Antioxidant Mechanisms in Neuronal Protection.Molecules (Basel, Switzerland) · 2026Review
- Anti-Inflammatory Effects of the Algal Diterpenoid Ruguloptone A by Modulation of M2 Response in Early Diabetic Retinopathy.Pharmaceutics · 2026Article
- Multi-Target-Directed Ligands (MTDLs) as Potential Therapeutic Candidates Targeting Multiple Pathogenic Factor of Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Review
- Pharmacological insights into deoxyelephantopin: a multifunctional sesquiterpene with therapeutic promise in cancer and neurodegenerative disorders.Molecular biology reports · 2026Review
- IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression.Neurotoxicity research · 2026Article
- ZEB1 and Neural Stem Cells: Insights into Microglia-Conditioned Medium-Driven Neuroinflammation.Cells · 2025Article
- Oxidative Stress, Inflammation, and Cellular Senescence in Neuropathic Pain: Mechanistic Crosstalk.Antioxidants (Basel, Switzerland) · 2025Review
- Modulation of nitric oxide signaling by flavonoids: implications for neurodegeneration.Molecular biology reports · 2025Review
- Hydnocarpin, a Natural Flavonolignan, Induces the ROS-Mediated Apoptosis of Ovarian Cancer Cells and Reprograms Tumor-Associated Immune Cells.Antioxidants (Basel, Switzerland) · 2025Article
- 2',4',6'-Trimethoxyacetophenone Isolated fromBiomolecules & therapeutics · 2025Article
- Ergolide Regulates Microglial Activation and Inflammatory-Mediated Dysfunction: A Role for the Cysteinyl Leukotriene Pathway.International journal of molecular sciences · 2025Article
- Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2025Review
- Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue.BMC complementary medicine and therapies · 2025Article
- Current Perspectives in Detection of Bioactive Compounds FromBiochemistry research international · 2025Article
- The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases.Molecular neurobiology · 2025Review
- Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging.Frontiers in aging neuroscience · 2025Article
- Chemical characterization, antioxidant capacity, and anti-inflammatory potentials invitro and in vivo of phenolic compounds extracted fromOpen veterinary journal · 2025Article
- Amantadine reduces sepsis-induced brain injury via NLRP3/caspase-1 inflammasome activation.Iranian journal of basic medical sciences · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation is one of the main mechanisms involved in the progression of neurodegeneration. The activation of microglia is the main feature of neuroinflammation, promoting the release of neurotoxic molecules and pro-inflammatory cytokines and resulting in the progressive neuronal cell death. Thus, suppression of the over-activation of microglia using novel pharmacological agents is an attractive issue to alleviate the neuroinflammatory processes associated with neurodegeneration. In recent years, medicinal plants-derived natural compounds have received extensive attention as useful sources of new neuroprotective agents for treating neurological disorders. In this review, we summarized the detailed research progress on the natural compounds derived from medicinal plants with potential anti-inflammatory effects and their molecular mechanisms on modulating the LPS-induced inflammatory responses in microglia. The natural compounds that efficacious in inhibiting the microglia activation include flavonoids, glycosides, phenolics, terpenoids, quinones, alkaloids, lignans, coumarins, chalcone, stilbene and others (biphenyl, phenylpropanoid, oxy carotenoid). They can reduce the expression of neurotoxic mediators (NO, PGE2, iNOS, COX-2) and pro-inflammatory cytokines (IL-6, TNF-α, IL-1β), down-regulate inflammatory markers and prevent neural damage. They exert anti-neuroinflammatory effects by modulating relevant signaling pathways (NF-κB, MAPKs, Nrf2/HO-1, PI3K/Akt, JAK/STAT) as demonstrated by experimental data. The present work reviews the role of microglia activation in neuroinflammation, highlighting the potential anti-inflammatory effects of natural compounds as a promising approach to develop innovative neuroprotective strategy.
Indexed as
Identifiers
32655777PMC7344058What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.