Evidence map›Paper›PMID 32655765›Full record

ArticleOxidative medicine and cellular longevity2020

Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model.

Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Hypoglycemic and Hypotensive Effects ofEvidence-based complementary and alternative medicine : eCAM · 2023
    Article
  2. Article
  3. Editorial: Prediabetes and endocrine function.Frontiers in endocrinology · 2023
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Akinjide Moses AkinnugaDepartment of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0001-7855-8176
Angezwa SibotoDepartment of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0001-9845-2301
Bongiwe KhumaloDepartment of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.
Ntethelelo Hopewell SibiyaDepartment of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South Africa.
Phikelelani NgubaneDepartment of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0003-2150-1149
Andile KhathiDepartment of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.ORCID https://orcid.org/0000-0002-2246-0038
University of KwaZulu-Natal · ZARhodes University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, studies have shown that renal dysfunction is associated not only with overt diabetes but also with the preceding stage known as prediabetes. Diet and pharmacological interventions are the therapeutic approaches to managing prediabetes, but the compliance in combining the two interventions is low. Hence, the efficacy of pharmacological intervention is reduced without diet modification. In our previous study, we established that bredemolic acid (BA) ameliorated glucose homeostasis via increased GLUT 4 expression in the skeletal muscle of prediabetic rats in the absence of diet intervention. However, the effects of bredemolic acid on renal function in prediabetic condition are unknown. Therefore, this study was aimed at investigating the ameliorative effects of bredemolic acid on renal dysfunction in a diet-induced prediabetic rat model. Thirty-six Sprague-Dawley male rats (150-180 g) were divided into two groups: the nonprediabetic (

Indexed as

AnimalsAntioxidantsBiomarkersDietDisease Models, AnimalHypoglycemic AgentsIntracellular Signaling Peptides and ProteinsKidneyKidney DiseasesLipid PeroxidationMaleMembrane ProteinsMetforminOleanolic AcidPrediabetic StateRatsAntioxidantsBiomarkersHypoglycemic AgentsIntracellular Signaling Peptides and Proteinsmaslinic acidMembrane ProteinsMetforminNPHS2 proteinOleanolic AcidTriterpenes

Identifiers

PMID32655765
PMCPMC7327579
OpenAlexW3036212040

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.