Evidence map›Paper›PMID 32655541›Full record

ArticleFrontiers in immunology2020

Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets.

Qi Hu, Cong Liu, Du Zhang, Ru Wang, Linlin Qin, Qin Xu, Lianqiang Che, Fei Gao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  11. Effects ofApplied and environmental microbiology · 2024
    Article
  12. Frontiers in veterinary science · 2024
    Review
  13. Article
  14. Article
  15. A review of the resistome within the digestive tract of livestock.Journal of animal science and biotechnology · 2021
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qi HuLingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Cong LiuLingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Du ZhangLingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Ru WangAnimal Nutrition Institute, Sichuan Agricultural University, Ya'an, China.
Linlin QinAnimal Nutrition Institute, Sichuan Agricultural University, Ya'an, China.
Qin XuAnimal Nutrition Institute, Sichuan Agricultural University, Ya'an, China.
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Ya'an, China.
Fei GaoLingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Sichuan Agricultural University · CNAgricultural Genomics Institute at Shenzhen · CNChinese Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Widespread antibiotic use increases the risk of livestock acting as potential reservoirs of antimicrobial resistance genes (ARGs) that may be transferred to human and animal pathogens. Particularly, maternal-infant transmission of antibiotics via breastmilk represents a great concern regarding infant health. In this study, we investigated the effects of 4-week low-dose antibiotic (LDA) treatment on the host immunity and antibiotic resistomes in weaned piglets. Transcriptomic analyses of ileum tissues revealed that the affected genes were largely enriched in innate immunity-related pathways. Significantly reduced protein expression of inflammatory factors, i.e.,

Indexed as

Drug Resistance, BacterialAnimalsAnti-Bacterial AgentsBacteriaBacterial ProteinsColonFemaleGastrointestinal MicrobiomeGene Expression ProfilingHost-Pathogen InteractionsIleumImmunity, InnateInterspersed Repetitive SequencesMetagenomicsMethyltransferasesSus scrofaAnti-Bacterial AgentsBacterial ProteinsErmTR protein, bacteriaMethyltransferasesantimicrobial resistance genesimmunityintestinelow-dose antibioticsmobile genetic elementsweaned piglet

Identifiers

PMID32655541
PMCPMC7325945
OpenAlexW3034780072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.