ArticleFrontiers in immunology2020
Gene-Dose Effect of
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Outcomes of living related kidney donors of recipients with familial mediterranean fever-associated Amyloid A Amyloidosis.Wiener klinische Wochenschrift · 2026Article
- Evaluation of Plasma Soluble Cd40 Ligand Levels in Children with Familial Mediterranean Fever and Its Relationship with Carotid Intima-Media Thickness.Diagnostics (Basel, Switzerland) · 2025Article
- Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment.Scientific reports · 2025Article
- Inflammatory biomarker analysis confirms reduced disease severity in heterozygous patients with familial Mediterranean fever.RMD open · 2024Article
- Immune-mediated inflammatory diseases (IMIDs) in children: key research questions and some answers.Molecular and cellular pediatrics · 2024Article
- Generation of iPSCs from a Patient with the M694V Mutation in theInternational journal of molecular sciences · 2024Article
- Epigenetic, transcriptional, and functional characterization of myeloid cells in familial Mediterranean fever.iScience · 2024Article
- NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain.Cell communication and signaling : CCS · 2024Article
- A narrative review on the role of cytokines in the pathogenesis and treatment of familial Mediterranean fever: an emphasis on pediatric cases.Frontiers in pediatrics · 2024Review
- Biological and clinical roles of IL-18 in inflammatory diseases.Nature reviews. Rheumatology · 2024Review
- Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever.Molecular and cellular pediatrics · 2023Article
- The NLRP3 inflammasome: contributions to inflammation-related diseases.Cellular & molecular biology letters · 2023Review
- NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain.Immune network · 2023Article
- A Well-Intentioned Enemy in Autoimmune and Autoinflammatory Diseases: NETosis.Turkish archives of pediatrics · 2023Article
- Pericarditis and Autoinflammation: A Clinical and Genetic Analysis of Patients With Idiopathic Recurrent Pericarditis and Monogenic Autoinflammatory Diseases at a National Referral Center.Journal of the American Heart Association · 2022Article
- Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation inLife (Basel, Switzerland) · 2022Article
- Excess Serum Interleukin-18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.Journal of clinical immunology · 2021Article
- Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.Nature reviews. Rheumatology · 2021Review
- Evaluation of S100A12 protein levels in children with familial Mediterranean feverTurkish journal of medical sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 1 country.
Iris StolerDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Judith FreytagDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Banu OrakDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nadine UnterwalderLaborBerlin - Charité Vivantes GmbH, Immunology Department, Berlin, Germany.
Stephan HenningPediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Katrin HeimDepartment of Infectious Diseases and Respiratory Medicine at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Horst von BernuthDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Renate KrügerDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Stefan WinklerDepartment of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Patience EschenhagenDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Eva SeipeltImmanuel Krankenhaus Berlin, Rheumatologie, Berlin, Germany.
Marcus A MallDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Dirk FoellDepartment of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Christoph KesselDepartment of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Helmut WittkowskiDepartment of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Tilmann KallinichDepartment of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEUniversity Hospital Münster · DEImmanuel Krankenhaus · DEUniversity Hospital Carl Gustav Carus · DEVivantes Klinikum · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial Mediterranean fever (FMF) is caused by mutations within the Mediterranean fever (
Indexed as
Gain of Function MutationGene DosageNeutrophil ActivationAdolescentAdultAgedAged, 80 and overCaspase 1Cells, CulturedChildCohort StudiesFamilial Mediterranean FeverFemaleHeterozygoteHumansInterleukin-18Caspase 1IL18 protein, humanInterleukin-18MEFV protein, humanPyrinS100A12 ProteinS100A12 protein, humanautoinflammationfamilial mediterranean feverIL-18NeutrophilS100A12
Identifiers
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.