Evidence map›Paper›PMID 32655524›Full record

ArticleFrontiers in microbiology2020

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating

Landys Lopez Quezada, Robert Smith, Tania J Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold, Julia Roberts, Yan Ling, Sae Woong Park, Quyen Nguyen and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Target Identification in Anti-Tuberculosis Drug Discovery.International journal of molecular sciences · 2023
    Review
  7. Identification of β-Lactams Active againstACS infectious diseases · 2022
    Article
  8. Anti-tuberculosis drug developmentFrontiers in microbiology · 2022
    Review
  9. Investigating β-Lactam Drug Targets inACS infectious diseases · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Landys Lopez QuezadaDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Robert SmithChemical Methodologies & Library Development Center, The University of Kansas, Lawrence, KS, United States.
Tania J LupoliDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Zainab EdooSorbonne Université, Sorbonne Paris Cité, Université de Paris, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Xiaojun LiDepartments of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States.
Ben GoldDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Julia RobertsDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Yan LingDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Sae Woong ParkDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Quyen NguyenDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Frank J SchoenenChemical Methodologies & Library Development Center, The University of Kansas, Lawrence, KS, United States.
Kelin LiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jean-Emmanuel HugonnetSorbonne Université, Sorbonne Paris Cité, Université de Paris, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Michel ArthurSorbonne Université, Sorbonne Paris Cité, Université de Paris, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
James C SacchettiniDepartments of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States.
Carl NathanDepartment of Microbiology & Immunology, Weill Cornell Medical College, New York, NY, United States.
Jeffrey AubéChemical Methodologies & Library Development Center, The University of Kansas, Lawrence, KS, United States.
Cornell University · USUniversity of North Carolina at Chapel Hill · USTexas A&M University · USUniversité Paris Cité · FRUniversity of Kansas · USInserm · FR

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI AUBE, JEFFREY, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
NIAID NIH HHS U19 AI111143
6 · The paper itself

Abstract

As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of

Indexed as

ABPPcephalosporinclick chemistryM. tuberculosisnon-replicatingβ-lactams

Identifiers

PMID32655524
PMCPMC7324553
OpenAlexW3037955443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.