ArticleFrontiers in neurology2020
Parietal Perfusion Alterations in Parkinson's Disease Patients Without Dementia.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Integrating retinal and brain imaging biomarkers for diagnosis of parkinson's disease: findings from a time-lagged cross-sectional persian cohort study.Scientific reports · 2026Article
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Cerebral activation following dynamic cycling in individuals with and without Parkinson's disease: an fNIRS investigation.Frontiers in human neuroscience · 2026Article
- Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.IBRO neuroscience reports · 2025Article
- Altered cerebral perfusion in Parkinson's disease patients with anxiety: an arterial spin labeling MRI study.Frontiers in neurology · 2025Article
- Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Magnetic Resonance Imaging and Nuclear Imaging of Parkinsonian Disorders: Where do we go from here?Current neuropharmacology · 2024Review
- Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Cardiac and Respiratory Influences on Intracranial and Neck Venous Flow, Estimated Using Real-Time Phase-Contrast MRI.Biosensors · 2022Article
- Mild cognitive impairment in patients with Parkinson's disease: An updated mini-review and future outlook.Frontiers in aging neuroscience · 2022Review
- Modulation of cortical resting state functional connectivity during a visuospatial attention task in Parkinson's disease.Frontiers in neurology · 2022Article
- Altered Prefrontal Blood Flow Related With Mild Cognitive Impairment in Parkinson's Disease: A Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- Magnetic Resonance Imaging Markers for Cognitive Impairment in Parkinson's Disease: Current View.Frontiers in aging neuroscience · 2022Review
- Consistent Cerebral Blood Flow Covariance Networks across Healthy Individuals and Their Similarity with Resting State Networks and Vascular Territories.Diagnostics (Basel, Switzerland) · 2020Article
- Early-phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fronto-parietal regions are involved in cognitive processes that are commonly affected in Parkinson's disease (PD). The aims of this study were to investigate cerebral blood flow (CBF) and gray matter (GM) volume within the regions belonging to the fronto-parietal circuit in people with PD (pwPD) without dementia, and to assess their association with cognitive performance. Twenty-seven pwPD without dementia (mean [SD] age = 67.4 [8.1] years, 20 males, mean [SD] Montreal Cognitive Assessment, MoCA score = 24.2 [2.9], median [IQR] Hoehn and Yahr scale = 1.5 [1-2]) and twenty-six age- and sex-matched healthy controls (HC) were scanned with arterial spin labeling (ASL) and T1-weighted magnetic resonance imaging (MRI) sequences to investigate CBF and GM volume, respectively. The cognitive performance of the enrolled pwPD was assessed with MoCA, Trail Making Test (TMT, part A, B, B-A), phonemic fluency and semantic fluency tests. The scores were adjusted for age and education. After standard preprocessing, CBF differences between pwPD and HC were tested with a voxel-wise approach. Voxel-based morphometry was used to compare pwPD and HC in terms of GM volume. Both voxel-wise comparisons between pwPD and HC were restricted to regions of the fronto-parietal circuit. The following additional voxel-wise analyses were performed within regions showing either perfusion or GM volume alterations: (1) correlation with neuropsychological test scores; (2) subgroup comparison after median split on each neuropsychological test score. Family-wise error-corrected (FWE)
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Registered trials
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