ArticleFrontiers in aging neuroscience2020
Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study.NeuroImage. Clinical · 2025Trial
- Pathophysiological Role of Perivascular Macrophages in Blood-Brain Barrier Dysfunction Induced by Cerebral Hypoperfusion in Mice.Neurochemical research · 2026Article
- Altered interactive relationships among neurofluid metrics in cerebral small vessel disease.Brain imaging and behavior · 2026Article
- Contrasting patterns of leptomeningeal and parenchymal gadolinium extravasation in cerebral amyloid angiopathy: An MRI-based evaluation.International journal of stroke : official journal of the International Stroke Society · 2026Article
- Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study.BMC medical imaging · 2025Article
- Assessment of Variability in Cerebral Blood Flow and Cerebral Blood Volume in Cerebral Arteries of Ischemic Stroke Patients Using Dynamic Contrast-Enhanced MRI.Tomography (Ann Arbor, Mich.) · 2025Article
- Article
- No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer's disease progression: a longitudinal study.GeroScience · 2025Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements in heterogeneous pediatric and adult populations.Frontiers in physiology · 2025Article
- Bridging the gap: Exploring the intercurrent relationship between knee osteoarthritis and cerebral small vessel disease.Caspian journal of internal medicine · 2025Review
- Establishment and evaluation of a clinical prediction model for cognitive impairment in patients with cerebral small vessel disease.BMC neuroscience · 2024Article
- A novel rat model of cerebral small vessel disease based on vascular risk factors of hypertension, aging, and cerebral hypoperfusion.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes.Brain sciences · 2023Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements.Frontiers in physiology · 2023Article
- Research progress on cognitive impairment and the expression of serum inflammatory markers in patients with white matter hyperintensities: a narrative review.Annals of translational medicine · 2022Review
- Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease.Frontiers in neurology · 2022Review
- A Novel Imaging Biomarker for Cerebral Small Vessel Disease Associated With Cognitive Impairment: The Deep-Medullary-Veins Score.Frontiers in aging neuroscience · 2021Article
- Gait Impairment and Upper Extremity Disturbance Are Associated With Total Magnetic Resonance Imaging Cerebral Small Vessel Disease Burden.Frontiers in aging neuroscience · 2021Article
- The Contribution of White Matter Diffusion and Cortical Perfusion Pathology to Vascular Cognitive Impairment: A Multimode Imaging-Based Machine Learning Study.Frontiers in aging neuroscience · 2021Article
- Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment.Frontiers in neurology · 2021Article
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6 authors.
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Abstract
backgroundCerebral small vessel disease (CSVD) is a common age-related vascular disease of the brain associated with slowly accumulating tissue damage. At present, total CSVD burden score is a commonly used method to evaluate the severity of the disease. PURPOSE: To observe whether global and regional cerebral perfusion is related to total CSVD score and to explore global and regional cerebral blood flow (CBF) changes in patients with different degrees of CSVD.
methodsWe collected 130 subjects with different total burden score of CSVD (0 point: 33 subjects, 1 point: 39 subjects, 2 points: 24 subjects, 3 points: 24 subjects, 4 points: 10 subjects). Total CSVD burden score was evaluated by clinically routine sequences (T2WI, T2-FLAIR, T1WI, DWI, and SWAN sequence). Global and regional CBF were calculated and correlation analysis was used to investigate the relationship between total CSVD score and CBF of the whole brain and several brain regions.
resultsThe analysis results showed that there was a negative correlation between total CSVD burden score and global CBF (
conclusionCSVD is a disease that affects the whole brain. With the increase of total CSVD burden score, the global and regional CBF decreased. The CSVD total burden score could be used to evaluate the overall condition of brain perfusion.
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