ArticleFrontiers in neuroscience2020
Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review.PloS one · 2021Pooled it
- Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage.Journal of neuroengineering and rehabilitation · 2025Trial
- From Trial to Chronic Epidural Electrical Stimulation: A Single-Patient Feasibility Study in Motor-Complete Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Traumatic Spinal Cord Injury: Review of the Literature.Journal of clinical medicine · 2025Review
- Article
- Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Different Factors Influencing Postural Stability during Transcutaneous Electrical Stimulation of the Cervical Spinal Cord.Journal of functional morphology and kinesiology · 2024Article
- Optimizing Transcutaneous Spinal Stimulation: Excitability of Evoked Spinal Reflexes is Dependent on Electrode Montage.Research square · 2024Article
- Consecutive Transcutaneous and Epidural Spinal Cord Neuromodulation to Modify Clinical Complete Paralysis-the Proof of Concept.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024Article
- Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke.Frontiers in bioengineering and biotechnology · 2024Article
- Spinal cord stimulation for spinal cord injury - Where do we stand? A narrative review.Journal of clinical orthopaedics and trauma · 2023Article
- Transcutaneous spinal stimulation in people with and without spinal cord injury: Effect of electrode placement and trains of stimulation on threshold intensity.Physiological reports · 2023Article
- Voluntary Modulation of Evoked Responses Generated by Epidural and Transcutaneous Spinal Stimulation in Humans with Spinal Cord Injury.Journal of clinical medicine · 2021Article
- Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.NPJ Regenerative medicine · 2021Article
- Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series.Animals : an open access journal from MDPI · 2021Article
- Spinal Locomotion in Cats Following Spinal Cord Injury: A Prospective Study.Animals : an open access journal from MDPI · 2021Article
- Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, we evaluated the role of residual supraspinal and afferent signaling and their convergence on the sublesional spinal network in subject diagnosed with complete paralysis (AIS-A).
methodsA combination of electrophysiologic techniques with positional changes and subject-driven reinforcement maneuvers was implemented in this study. Electrical stimulation was applied transcutaneously at the T9-L2 vertebra levels and the spinal cord motor evoked potentials (SEMP) were recorded from leg muscles. To test the influence of positional changes, the subject was placed in (i) supine, (ii) upright with partial body weight bearing and (iii) vertically suspended without body weight bearing positions.
resultsIncrease in amplitude of SEMP was observed during transition from supine to upright position, supporting the role of sensory input in lumbosacral network excitability. Additionally, amplitudes of SEMP were facilitated during reinforcement maneuvers, indicating a supralesional influence on sub-lesional network. After initial assessment, subject underwent rehabilitation therapy with following electrophysiological testing that reviled facilitation of SEMP.
conclusionThese results demonstrate that combination of electrophysiological techniques with positional and reinforcement maneuvers can add to the diagnostics of discomplete SCI. These findings also support an idea that integration of supraspinal and afferent information on sub-lesional circuitry plays a critical role in facilitation of spinal sensorimotor network in discomplete SCI.
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