Evidence map›Paper›PMID 32655332›Full record

ArticleJournal of statistical software2016

CLME: An R Package for Linear Mixed Effects Models under Inequality Constraints.

Casey M Jelsema, Shyamal D Peddada

Open access · diamondAbstract read
In one paragraph

Article in Journal of statistical software, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

282 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  8. Evaluation of post-laryngectomy dysphagia rehabilitation using High-Resolution impedance manometry: an exploratory study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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  15. A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
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  16. A randomized controlled trial of a 14-day mindfulness ecological momentary intervention (MEMI) for generalized anxiety disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023
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  19. Empagliflozin in acute myocardial infarction: the EMMY trial.European heart journal · 2022 · on this map
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222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Casey M JelsemaNational Institute of Environmental Health Sciences (NIEHS).
Shyamal D PeddadaNational Institute of Environmental Health Sciences (NIEHS).
National Institute of Environmental Health Sciences · USOrszagos Kornyezetegeszsegugyi Intezet · HU

Funding

Statistical Theory and Methodology with Applications toZ01ES101744 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PEDDADA, SHYAMAL · 2004 to 2008
$803k
Intramural NIH HHS Z01 ES101744
6 · The paper itself

Abstract

In many applications researchers are typically interested in testing for inequality constraints in the context of linear fixed effects and mixed effects models. Although there exists a large body of literature for performing statistical inference under inequality constraints, user friendly statistical software for implementing such methods is lacking, especially in the context of linear fixed and mixed effects models. In this article we introduce

Indexed as

distribution freelinear fixed effects modelslinear inequality constraintslinear mixed effects modelsorder restricted inferenceRresidual bootstrap

Identifiers

PMID32655332
PMCPMC7351245
OpenAlexW2549242197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.