Evidence map›Paper›PMID 32655298›Full record

ArticleCurrent genomics2020

Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepato-cellular Carcinoma.

Marwa Matboli, Mariam E Labib, Hanaa El-Tayeb Nasser, Ahmed H F El-Tawdi, Eman K Habib, Randa Ali-Labib

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In one paragraph

Article in Current genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Combinatorial Gene Expression Profiling of SerumInternational journal of molecular sciences · 2024
    Pooled it
  3. Pooled it
  4. Review
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  11. Exosomal Long Noncoding RNAs Serve as Biomarkers for Liver Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Review
  12. Review
  13. Article
  14. Exosomes as potential diagnosis and treatment for liver cancer.World journal of gastrointestinal oncology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marwa Matboli1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Mariam E Labib1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Hanaa El-Tayeb Nasser1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Ahmed H F El-Tawdi1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Eman K Habib1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Randa Ali-Labib1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study was to explore the expression of exosomal non-coding RNAs (ncRNAs) in the sera of patients with HCC

methodsFirstly, Bioinformatics analysis was conducted to retrieve ncRNAs specific to HCC (hsa-miRNA-1298 and lncRNA-RP11-583F2.2). Afterwards, extraction and characterization of exosomes were performed. We measured the expression of the chosen exosomal RNAs by reverse transcriptase quantitative real-time PCR in sera of 60 patients with HCC, 42 patients with chronic hepatitis C (CHC) infection and 18 healthy normal volunteers.

resultsThe exosomal ncRNAs [hsa-miRNA-1298, lncRNA-RP11-583F2.2] had better sensitivity and specificity than alpha-fetoprotein (AFP) in HCC diagnosis.

conclusionThe exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis.

Indexed as

chronic hepatitis CdiagnosisexosomeHepatocellular carcinomalncRNAmiRNA

Identifiers

PMID32655298
PMCPMC7324892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.