Evidence map›Paper›PMID 32655264›Full record

ReviewWorld journal of gastroenterology2020

Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application.

Yue Gao, Jun-Wei Wang, Jia-Yi Ren, Mian Guo, Cheng-Wang Guo, Shang-Wei Ning, Shan Yu

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yue GaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Jun-Wei WangDepartment of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Jia-Yi RenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Mian GuoDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Cheng-Wang GuoDepartment of Gastroenterology and Gastrosurgery, Gansu Wuwei Tumor Hospital, Wuwei 733000, Gansu Province, China.
Shang-Wei NingCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
Shan YuDepartment of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China. yushan@hrbmu.edu.cn.
Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CNHuawei Technologies (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are important regulators of cell processes that are usually dysregulated in gastric cancer (GC). Based on their high specificity and ease of detection in tissues and body fluids, increasing attention has spurred the study of the roles of lncRNAs in GC patients. Thus, it is necessary to elucidate the molecular mechanisms and further explore the clinical applications of lncRNAs in GC. In this review, we summarize current knowledge to examine dysregulated lncRNAs in GC and their underlying molecular mechanisms and activities in GC, which involve microRNA sponging, mRNA stability, genetic variants, alternative splicing, transcription factor binding, and epigenetic modification. More significantly, the potential of lncRNAs as prognostic, circulating, and drug-resistant biomarkers for GC is also described. This review highlights the method of dissecting molecular mechanisms to explore the clinical application of lncRNAs in GC. Overall, this review offers assistance in using lncRNAs as novel candidates for molecular mechanisms and for the identification of revolutionary biomarkers for GC.

Indexed as

RNA, Long NoncodingStomach NeoplasmsBiomarkers, TumorDissectionGene Expression Regulation, NeoplasticHumansBiomarkers, TumorRNA, Long NoncodingBiomarkersDrug resistanceGastric cancerLong noncoding RNAsMolecular mechanismTherapeutic target

Identifiers

PMID32655264
PMCPMC7327794
OpenAlexW3037177218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.