ArticleEndoscopic ultrasound
A new needle-based confocal laser endomicroscopy pattern of malignant pancreatic mucinous cystic lesions (with video).
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Real-time guidance of lauromacrogol ablation for pancreatic cystic lesions using confocal laser endomicroscopy.Therapeutic advances in gastroenterology · 2026Article
- Endoscopic management of pancreatic cystic neoplasms.World journal of gastrointestinal oncology · 2025Review
- Mucinous cystic neoplasm mimicking pancreatic pseudocyst and progressing to adenocarcinoma: A case report.World journal of gastrointestinal oncology · 2025Article
- Diagnostic yield and safety of pancreatic cystic lesions: A comparison between EUSZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Comparative accuracy of four guidelines to predict high-grade dysplasia or malignancy in surgically resected pancreatic intraductal papillary mucinous neoplasms: Small nuances between guidelines lead to vastly different results.Annals of hepato-biliary-pancreatic surgery · 2024Article
- Recent advances in the diagnostic evaluation of pancreatic cystic lesions.World journal of gastroenterology · 2022Review
- Intraoperative confocal laser endomicroscopy for brain tumors - potential and challenges from a neuropathological perspective.Free neuropathology · 2022Article
- Application of EUS-based techniques in the evaluation of pancreatic cystic neoplasms.Endoscopic ultrasoundReview
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe diagnosis of malignant pancreatic cystic lesions (PCLs) remains challenging. Needle-based confocal laser endomicroscopy (nCLE) is an emerging promising imaging technique capable of real-time in vivo microscopic imaging of the cyst wall. We aimed to develop and validate a new nCLE diagnostic criteria for malignant mucinous cystic lesions (MLs).
methodsPatients referred for EUS-FNA of indeterminate PCLs with at least one worrisome features according to Fukouka consensus were consecutively prospectively enrolled from July 2016 to July 2018. The final diagnosis was based on surgical histology, cytopathology, or committee consensus. Five investigators nonblindly reviewed nCLE features and identified potential diagnostic feature for malignant MLs, which was also reviewed in histology imaging accordingly. Furthermore, the nCLE diagnostic feature was evaluated with an independent nCLE dataset by two investigators in a double-blind manner.
resultsA nCLE pattern of dark aggregates of neoplastic cells was identified as diagnostic for MLs, which was consistent with histological findings of irregular branching and budding in malignant MLs. An independent validation revealed that the accuracy, sensitivity, and specificity of this feature for the diagnosis of malignant MLs were 94%, 75%, and 100%, respectively.
conclusionThe new nCLE criterion is promising for diagnosis of malignant MLs which warrants further confirmation in large cohort.
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