ArticleCancer prevention research (Philadelphia, Pa.)2020
Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer.
Registry-linked trialOpen access · bronzeAbstract readComment
In one paragraph
Article in Cancer prevention research (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Analysis of Body Mass Index in Early and Middle Adulthood and Estimated Risk of Gastrointestinal Cancer.JAMA network open · 2023Trial
- Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber.Cancer prevention research (Philadelphia, Pa.) · 2021Trial
- Review
- Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort.The American journal of clinical nutrition · 2025Article
- Defining a 'cells to society' research framework for appendiceal tumours.Nature reviews. Cancer · 2025Review
- Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer.Journal for immunotherapy of cancer · 2025Article
- Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gene and lncRNA Profiling of ω3/ω6 Polyunsaturated Fatty Acid-Exposed Human Visceral Adipocytes Uncovers Different Responses in Healthy Lean, Obese and Colorectal Cancer-Affected Individuals.International journal of molecular sciences · 2024Article
- Metabolomics of 3D cell co-culture reveals alterations in energy metabolism at the cross-talk of colorectal cancer-adipocytes.Frontiers in medicine · 2024Article
- Emerging technologies in adipose tissue research.Adipocyte · 2023Review
- Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?International journal of molecular sciences · 2022Review
- Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Consensus molecular subtype differences linking colon adenocarcinoma and obesity revealed by a cohort transcriptomic analysis.PloS one · 2022Article
- Article
- Article
- iMAP: A Web Server for Metabolomics Data Integrative Analysis.Frontiers in chemistry · 2021Article
- Obesity, Type 2 Diabetes, and Cancer Risk.Frontiers in oncology · 2020Review
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Authors and funding
34 authors at 13 institutions in 6 countries.
Andreana N HolowatyjHuntsman Cancer Institute, Salt Lake City, Utah. andreana.holowatyj@vumc.org neli.ulrich@hci.utah.edu.ORCID 0000-0001-8001-8793
Mariam HaffaGerman Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-0156-7749
Tengda LinHuntsman Cancer Institute, Salt Lake City, Utah.
Dominique SchererUniversity of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4430-296X
Biljana GigicUniversity of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-8085-2072
Jennifer OseHuntsman Cancer Institute, Salt Lake City, Utah.ORCID 0000-0002-2030-9676
Christy A WarbyHuntsman Cancer Institute, Salt Lake City, Utah.
Caroline HimbertHuntsman Cancer Institute, Salt Lake City, Utah.ORCID 0000-0003-4084-8340
Clare Abbenhardt-MartinGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
David AchaintreInternational Agency for Research on Cancer (IARC), Lyon, France.
Juergen BoehmHuntsman Cancer Institute, Salt Lake City, Utah.
Kenneth M BoucherHuntsman Cancer Institute, Salt Lake City, Utah.ORCID 0000-0003-2833-0127
Audrey GicquiauInternational Agency for Research on Cancer (IARC), Lyon, France.
Andrea GsurInstitute of Cancer Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9795-1528
Nina HabermannEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Esther HerpelNational Center for Tumor Diseases (NCT), Heidelberg, Germany.
Hans-Ulrich KauczorUniversity of Heidelberg, Heidelberg, Germany.
Pekka Keski-RahkonenInternational Agency for Research on Cancer (IARC), Lyon, France.
Matthias KloorEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Magnus von Knebel-DoeberitzEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0002-0498-6781
Dieuwertje E KokWageningen University and Research, Wageningen, The Netherlands.ORCID 0000-0001-7154-8207
Johanna NattenmüllerUniversity of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4032-378X
Peter SchirmacherNational Center for Tumor Diseases (NCT), Heidelberg, Germany.ORCID 0000-0003-4339-3492
Martin SchneiderUniversity of Heidelberg, Heidelberg, Germany.
Petra Schrotz-KingGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas SimonGRN-Clinic, Weinheim, Germany.
Per M UelandMaastricht University, Maastricht, the Netherlands.ORCID 0000-0002-1903-0571
Richard ViskochilHuntsman Cancer Institute, Salt Lake City, Utah.
Matty P WeijenbergBEVITAL, Bergen, Norway.ORCID 0000-0003-1695-4768
Augustin ScalbertInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0001-6651-6710
Alexis UlrichUniversity of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-1469-2186
Laura W BowersPurdue University, West Lafayette, Indiana.
Stephen D HurstingUniversity of North Carolina, Chapel Hill, North Carolina.
Cornelia M UlrichHuntsman Cancer Institute, Salt Lake City, Utah. andreana.holowatyj@vumc.org neli.ulrich@hci.utah.edu.ORCID 0000-0003-1469-2186
Heidelberg University · DEUniversity of Utah · USCentre international de recherche sur le cancer · FREuropean Molecular Biology Organization · DEGerman Cancer Research Center · DEUniversity of North Carolina at Chapel Hill · USBevital (Norway) · NOComprehensive Cancer Center Vienna · ATGerresheimer (Germany) · DEHuntsman Cancer Institute · USMaastricht University · NLVanderbilt University · USWageningen University & Research · NL
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUtah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MHigher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer ChemoresistanceR35CA197627 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HURSTING, STEPHEN D · 2015 to 2021
$6.0MDiscovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6MMetabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9MCancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7MTraining Program in Genomic MedicineT32HG008962 · NHGRI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Lynn Jorde, Aaron R Quinlan · 2016 to 2026
$3.0MPrecision-exercise-prescription for Lung Cancer Patients Undergoing Surgery: The PEP StudyR01CA211705 · NCI · UNIVERSITY OF UTAH · PI LASTAYO, PAUL C, ULRICH, CORNELIA M · 2017 to 2021
$2.2MNCATS NIH HHS UL1 TR002538NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA207371NCI NIH HHS R01 CA211705NCI NIH HHS R35 CA197627NCI NIH HHS T32 CA057726NCI NIH HHS U01 CA206110NHGRI NIH HHS T32 HG008962NIEHS NIH HHS P30 ES010126World Health Organization 001
Abstract
Obesity and obesity-driven cancer rates are continuing to rise worldwide. We hypothesize that adipocyte-colonocyte interactions are a key driver of obesity-associated cancers. To understand the clinical relevance of visceral adipose tissue in advancing tumor growth, we analyzed paired tumor-adjacent visceral adipose, normal mucosa, and colorectal tumor tissues as well as presurgery blood samples from patients with sporadic colorectal cancer. We report that high peroxisome proliferator-activated receptor gamma (
Indexed as
Adipose TissueColorectal NeoplasmsCarcinogenesisHumansIntra-Abdominal FatObesityTumor Microenvironment
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Read underepoch 390
Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.