Evidence map›Paper›PMID 32654859›Full record

ArticleSurgery2021

What is the experience of our patients with transient hypoparathyroidism after total thyroidectomy?

Amanda R Doubleday, Sarah E Robbins, Cameron L Macdonald, Dawn M Elfenbein, Nadine P Connor, Rebecca S Sippel

Open access · greenAbstract read
In one paragraph

Article in Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amanda R DoubledayDivision of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address: doubleday@surgery.wisc.edu.
Sarah E RobbinsDivision of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Cameron L MacdonaldQualitative Health Research Consultants, LLC, Madison, WI.
Dawn M ElfenbeinDivision of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Nadine P ConnorDivision of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Rebecca S SippelDivision of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Central Neck Dissection in Patients with Clinical Node Negative Thyroid CancerR01CA176911 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P, SIPPEL, REBECCA S · 2014 to 2019
$1.8M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA176911
6 · The paper itself

Abstract

backgroundWe sought to better understand the experience of patients with transient hypoparathyroidism using patient interviews and quality of life surveys.

methodsThis is a prospective analysis of 62 patients after total thyroidectomy at a high-volume institution. Semistructured patient interviews and quality of life surveys were conducted preoperatively and postoperatively at 2 weeks, 6 weeks, 6 months, and 1 year and compared based on postoperative parathyroid hormone levels.

resultsPostoperative parathyroid hormone levels were <10 pg/mL in 32% of patients (n = 20), 10 to 20 pg/mL in 19% (n = 12), and >20 pg/mL in 48% (n = 30). Hypocalcemic symptoms at 2 weeks were reported in 28 of 55 patients (51%), but patients felt "well prepared" and reported it "wasn't a big deal." If symptoms persisted at 6 weeks, they became more bothersome. At 6 months and 1 year, patients reported calcium supplementation prevented most symptoms and did not interfere with daily activities. Quality of life as measured by the European Organization for Research and Treatment of Cancer and the 12-Item Short Form Survey demonstrated a slight improvement at 1 year postoperatively regardless of parathyroid hormone level.

conclusionEarly postoperative transient hypoparathyroidism is common but when appropriately managed did not have a substantial negative impact on the overall quality of life.

Indexed as

Quality of LifeAdultAgedCalciumFemaleFollow-Up StudiesHumansHypocalcemiaHypoparathyroidismMaleMiddle AgedParathyroid GlandsParathyroid HormonePostoperative ComplicationsPreoperative PeriodProspective StudiesCalciumParathyroid Hormone

Identifiers

PMID32654859
PMCPMC8641920
OpenAlexW3040884405

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.