ArticleThe Journal of membrane biology1988
Odorant response of isolated olfactory receptor cells is blocked by amiloride.
Article in The Journal of membrane biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Odor tracking in aquatic organisms: the importance of temporal and spatial intermittency of the turbulent plume.Scientific reports · 2020Article
- Fat Body Organ Culture System in Aedes Aegypti, a Vector of Zika Virus.Journal of visualized experiments : JoVE · 2017Article
- Smelling Time: A Neural Basis for Olfactory Scene Analysis.Trends in neurosciences · 2016Review
- Neurally Encoding Time for Olfactory Navigation.PLoS computational biology · 2016Article
- Intermittency coding in the primary olfactory system: a neural substrate for olfactory scene analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Octopamine and tyramine modulate pheromone-sensitive olfactory sensilla of the hawkmoth Manduca sexta in a time-dependent manner.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Model of calcium oscillations due to negative feedback in olfactory cilia.Biophysical journal · 2006Article
- An estimate of the resting membrane resistance of frog olfactory receptor neurones.The Journal of physiology · 2004Article
- Contribution of cyclic-nucleotide-gated channels to the resting conductance of olfactory receptor neurons.Biophysical journal · 2003Article
- Odorant-induced olfactory receptor neural oscillations and their modulation of olfactory bulbar responses in the channel catfish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Simultaneous recording of receptor current and intraciliary Ca2+ concentration in salamander olfactory receptor cells.The Journal of physiology · 2001Article
- Responses to prolonged odour stimulation in frog olfactory receptor cells.The Journal of physiology · 2001Article
- Adaptation of the odour-induced response in frog olfactory receptor cells.The Journal of physiology · 1999Article
- A depolarizing chloride current contributes to chemoelectrical transduction in olfactory sensory neurons in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Single-channel currents trigger action potentials in small cultured hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists.British journal of pharmacology · 1994Article
- Action potentials and chemosensitive conductances in the dendrites of olfactory neurons suggest new features for odor transduction.The Journal of general physiology · 1994Article
- Basal conductance of frog olfactory cilia.Pflugers Archiv : European journal of physiology · 1992Article
- An analysis of Na+ currents in rat olfactory receptor neurons.Pflugers Archiv : European journal of physiology · 1992Article
- Chemosensory responses in isolated olfactory receptor neurons from Necturus maculosus.The Journal of general physiology · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor cells were isolated from the nasal mucosa of Rana esculenta and patch clamped. Best results were obtained with free-floating cells showing ciliary movement. 1) On-cell mode: Current records were obtained for up to 50 min. Under control conditions they showed only occasional action potentials. The odorants cineole, amyl acetate and isobutyl methoxypyrazine were applied in saline by prolonged superfusion. At 500 nanomolar they elicited periodic bursts of current transients arising from cellular action potentials. The response was rapidly, fully and reversibly blocked by 50 microM amiloride added to the odorant solution. With 10 microM amiloride, the response to odorants was only partially abolished. 2) Whole-cell mode: Following breakage of the patch, the odorant response was lost within 5 to 15 min. Prior to this, odorants evoked a series of slow transient depolarizations (0.1/sec, 45 mV peak to peak) which reached threshold and thus elicited the periodic discharge of action potentials. These slow depolarizing waves were reversibly blocked by amiloride, which stabilized the membrane voltage between -80 and -90 mV. We conclude that amiloride inhibits chemosensory transduction of olfactory receptor cells, probably by blocking inward current pathways which open in response to odorants.
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