Evidence map›Paper›PMID 32654405›Full record

ArticleFEBS open bio2020

High-resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.

Jonathan R Davies, Amy Britton, Sai Man Liu, K Ravi Acharya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Crystal Structures of theInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Jonathan R DaviesDepartment of Biology and Biochemistry, Claverton Down, University of Bath, Bath, UK.ORCID 0000-0002-4986-8594
Amy BrittonDepartment of Biology and Biochemistry, Claverton Down, University of Bath, Bath, UK.
Sai Man LiuIpsen Bioinnovation Limited, Milton Park, Abingdon, UK.ORCID 0000-0001-6359-0229
K Ravi AcharyaDepartment of Biology and Biochemistry, Claverton Down, University of Bath, Bath, UK.ORCID 0000-0002-3009-4058
University of Bath · GBIpsen (United Kingdom) · GBStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (H

Indexed as

Botulinum Toxins, Type ACrystallography, X-RayModels, MolecularProtein ConformationBotulinum Toxins, Type Abinding domain structurebotulinum neurotoxinClostridium botulinumsubtypesX-ray crystallography

Identifiers

PMID32654405
PMCPMC7396429
OpenAlexW3041368967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.