Evidence map›Paper›PMID 32654350›Full record

ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2020

Decrease of Non-Classical and Intermediate Monocyte Subsets in Severe Acute SARS-CoV-2 Infection.

Arianna Gatti, Danilo Radrizzani, Paolo Viganò, Antonino Mazzone, Bruno Brando

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Coordinated expansion of CD163bioRxiv : the preprint server for biology · 2026
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  5. CD169Frontiers in cellular and infection microbiology · 2026
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  6. Induction of dysfunctional CD14Frontiers in immunology · 2026
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  7. Review
  8. Buffalo Immune Competence Under Infectious and Non-Infectious Stressors.Animals : an open access journal from MDPI · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. iScience · 2023
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Arianna GattiHematology Laboratory and Transfusion Center, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
Danilo RadrizzaniDepartment of Intensive Care, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
Paolo ViganòDepartment of Infectious Diseases, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
Antonino MazzoneDepartment of Internal Medicine, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
Bruno BrandoHematology Laboratory and Transfusion Center, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.ORCID 0000-0002-9163-1515
Azienda Ospedaliera Ospedale Civile di Legnano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non-classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study, 30 patients with different manifestations of acute SARS-CoV-2 infection were investigated with a flow cytometric study of NC, INT, and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. © 2020 International Society for Advancement of Cytometry.

Indexed as

AgedBetacoronavirusBiomarkersCD11b AntigenCell SeparationCoronavirus InfectionsCOVID-19FemaleFlow CytometryHost Microbial InteractionsHumansLeukocytesMaleMiddle AgedMonocytesPandemicsBiomarkersCD11b AntigenITGAM protein, humanclassical monocytesCOVID-19intermediate monocytesmonocytesmulticolor flow cytometrynon-classical monocytesSARS-CoV2

Identifiers

PMID32654350
PMCPMC7404377
OpenAlexW3041842588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.