Evidence map›Paper›PMID 32654348›Full record

SynthesisJournal of thrombosis and haemostasis : JTH2020

Risk scores for occult cancer in patients with unprovoked venous thromboembolism: Results from an individual patient data meta-analysis.

Frits I Mulder, Marc Carrier, Frederiek van Doormaal, Philippe Robin, Hans-Martin Otten, Pierre-Yves Salaun, Harry R Büller, Grégoire Le Gal, Nick van Es

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. External validation of the RIETE and SOME scores for occult cancer in patients with venous thromboembolism: a multicentre cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. [Chinese guidelines for diagnosis, prevention and treatment of thrombophilia (2021)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Frits I MulderDepartment of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.ORCID 0000-0002-6902-3425
Marc CarrierDepartment of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON, Canada.
Frederiek van DoormaalDepartment of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Philippe RobinService de Médecine Nucléaire, Centre Hospitalier Régional et Universitaire de Brest, EA 3878 (GETBO), Université de Bretagne Occidentale, Brest, France.
Hans-Martin OttenDepartment of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands.
Pierre-Yves SalaunService de Médecine Nucléaire, Centre Hospitalier Régional et Universitaire de Brest, EA 3878 (GETBO), Université de Bretagne Occidentale, Brest, France.
Harry R BüllerDepartment of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Grégoire Le GalDepartment of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON, Canada.
Nick van EsDepartment of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLUniversité de Bretagne Occidentale · FRUniversity of Ottawa · CAMeander Medisch Centrum · NLTergooi · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Registro Informatizado de Pacientes con Enfermedad TromboEmbólica (RIETE) score and the Screening for Occult Malignancy in Patients with Idiopathic Venous Thromboembolism (SOME) risk scores aim to identify patients with acute unprovoked venous thromboembolism (VTE) at high risk of occult cancer, but their predictive performance is unclear.

methodsThe scores were evaluated in an individual patient data meta-analysis. Studies were eligible if enrolling consecutive adults with unprovoked VTE who underwent protocol-mandated screening for cancer. The primary outcome was a cancer diagnosis between 30 days and 2 years of follow-up. The discriminatory performance was evaluated by computing the area under the receiver (ROC) curve in random-effects meta-analyses.

resultsThe RIETE score could be calculated in 1753 patients, of whom 63 (3.6%) were diagnosed with cancer. The pooled area under the ROC curve was 0.59 (95% confidence interval [CI], 0.52-0.66; I

conclusionsThe predictive discriminatory performance of both scores is poor. When used dichotomously, the RIETE score is able to discriminate between low- and high-risk patients. Because this is largely driven by advanced age, these results do not support the use of these scores in daily clinical practice.

Indexed as

NeoplasmsVenous ThromboembolismAdultHumansRisk FactorsROC Curvecancerdiagnosisearly detection of cancerneoplasmsvenous thromboembolism

Identifiers

PMID32654348
PMCPMC7590094
OpenAlexW3041165963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.