Evidence map›Paper›PMID 32654332›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients: A cohort study.

Zohra S Chaudhry, Jonathan D Williams, Amit Vahia, Raef Fadel, Tommy Parraga Acosta, Rohini Prashar, Pritika Shrivastava, Nadeen Khoury, Julio Pinto Corrales, Celeste Williams and 8 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 7 pooled it
3.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 7 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  2. COVID-19 and solid organ transplantation: Finding the right balance.Transplantation reviews (Orlando, Fla.) · 2022
    Pooled it
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  16. Severe COVID-19 in 2 Kidney Transplant Patients in Gabon.The American journal of case reports · 2022
    Article
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  18. Review
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  20. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia · 2022
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Zohra S ChaudhryDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.ORCID 0000-0002-8733-2264
Jonathan D WilliamsDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Amit VahiaDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Raef FadelDepartment of Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Tommy Parraga AcostaDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Rohini PrasharDivision of Nephrology, Henry Ford Transplant Institute, Detroit, Michigan, USA.ORCID 0000-0002-0102-8684
Pritika ShrivastavaDivision of Nephrology, Henry Ford Transplant Institute, Detroit, Michigan, USA.ORCID 0000-0002-7085-2933
Nadeen KhouryDivision of Nephrology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
Julio Pinto CorralesDivision of Pulmonology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
Celeste WilliamsDivision of Cardiology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
Shunji NagaiDivision of Hepatology, Henry Ford Transplant Institute, Detroit, Michigan, USA.ORCID 0000-0003-2612-8427
Marwan AbouljoudDivision of Hepatology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
Milagros Samaniego-PicotaDivision of Nephrology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
Odaliz Abreu-LanfrancoDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Ramon Del BustoDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Mayur S RameshDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.
Anita PatelDivision of Nephrology, Henry Ford Transplant Institute, Detroit, Michigan, USA.
George J AlangadenDivision of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan, USA.ORCID 0000-0001-8076-776X
Henry Ford Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID-19) are expected to have poorer outcomes compared to nontransplant patients because of immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. Twelve of 47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs 57% P = .0007), diabetes (66% vs 33% P = .0007), and hypertension (94% vs 72% P = .006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs 17%, P < .0001) was more frequent in SOTr. Primary composite outcome (escalation to intensive care unit, mechanical ventilation, or in-hospital all-cause mortality) was comparable between SOTr and controls (40% vs 48%, odds ratio [OR] 0.72 confidence interval [CI] [0.33-1.58] P = .42), despite more comorbidities in SOTr. Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64-22] P = .007). Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. Transplant status itself was not associated with mortality.

Indexed as

Organ TransplantationPandemicsSARS-CoV-2Transplant RecipientsAgedComorbidityCOVID-19FemaleGraft RejectionHumansImmunosuppression TherapyIncidenceIntensive Care UnitsMaleMiddle AgedRetrospective Studiesclinical research/practicecomplication: infectiousinfection and infectious agents - viralinfectious diseasekidney transplantation/nephrologyorgan transplantation in general

Identifiers

PMID32654332
PMCPMC7405160
OpenAlexW3041531776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.