Evidence map›Paper›PMID 32654324›Full record

ArticleBrain pathology (Zurich, Switzerland)2020

The molecular etiology of Alzheimer's disease.

Adam R Smith, Jonathan Mill, Katie Lunnon

Abstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Brain Pathology moves to open access.Brain pathology (Zurich, Switzerland) · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam R SmithUniversity of Exeter Medical School, Exeter University, Exeter, UK.ORCID 0000-0001-6495-2711
Jonathan MillUniversity of Exeter Medical School, Exeter University, Exeter, UK.ORCID 0000-0003-1115-3224
Katie LunnonUniversity of Exeter Medical School, Exeter University, Exeter, UK.ORCID 0000-0001-7570-6065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a growing global healthcare epidemic. Owing to advances in technology, genome-scale studies of various layers of molecular information have been undertaken in recent years and robust variation in key loci have now been published and reproduced by others. This mini-symposium highlights four key areas of current research in the field of molecular biology in AD, including articles focused on large-scale genomic profiling, epigenetic research, integrative multi-omic approaches and how these can be appropriately modeled to address reverse causality. This mini-symposium provides a timely update on research focused on elucidating the molecular etiology of AD to date and highlights new methodological advances that could enable neuroscientists to identify novel therapeutic targets.

Indexed as

Alzheimer DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansAlzheimer’s diseaseepigeneticsgene editinggeneticsintegrative genomics

Identifiers

PMID32654324
PMCPMC8018060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.