ReviewCurrent rheumatology reports2020
Epigenetics for Clinicians from the Perspective of Pediatric Rheumatic Diseases.
Review in Current rheumatology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases.Clinical and experimental medicine · 2024Review
- Genetics in Behcet's Disease: An Update Review.Frontiers in ophthalmology · 2022Review
- Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet's Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewEpigenetics is the study of inherited phenotype changes that do not involve in alteration of DNA sequence. Epigenetic regulation can be examined under three main headings and study methodologies for all three will be discussed: DNA methylation is the addition of a methyl (CH RECENT
findingsRecent studies have assessed DNA hypomethylation in interferon-regulated genes in autoimmune diseases and in inflammatory pathways in systemic autoinflammatory diseases (SAIDs). Abnormal histone acetylation and methylation have been shown to be important in autoimmune diseases which was proven via effective targeted treatment trials against these pathways in mice models. miRNAs have an important role in the pathogenesis, and also, they can be used as diagnostic biomarkers in SAIDs (i.e., FMF, Behcet's disease) together with autoimmune diseases. Although the number of studies has increased over the years in parallel with the increase of interest in this field, we await further studies to improve the understanding and management of pediatric rheumatic diseases. Epigenetic studies in pediatric rheumatic diseases have enabled us to gain new information about disease pathogenesis, clinical heterogeneity, and prognosis. Further studies will help us define new diagnostic, prognostic, and therapeutic goals for rheumatic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.