ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Effects of acute mild hypoxia on cerebral blood flow in pilots.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of Transcutaneous Vagus Nerve Stimulation on Cerebral Perfusion and Cognitive Function Under Simulated High-Altitude Hypobaric Hypoxia.Brain and behavior · 2026Trial
- Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy.World journal of radiology · 2026Article
- Oxygen-dependent functional brain haemodynamic response.Biomedical optics express · 2025Article
- Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude.Frontiers in neuroscience · 2025Article
- Cerebrovascular autoregulation in hypoxia: quantitative insights from arterial spin labeling.Frontiers in neuroscience · 2025Review
- Oxidative Stress Reaction to Hypobaric-Hyperoxic Civilian Flight Conditions.Biomolecules · 2024Article
- Impairment of attention network function in posterior circulation ischemia-evidence from the Attention Network Test.Frontiers in human neuroscience · 2022Article
- Return-to-fly after flow diversion for unruptured paraclinoid aneurysms in military pilots.Frontiers in neurologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPilots often face and need to overcome a diverse range of unfavorable conditions, of which hypoxic exposure is the most common. Studies have reported that hypoxia can induce a decrease in cerebral blood flow (CBF) in the brains of both humans and animals. Hypoxia and the associated cerebral hemodynamic changes can contribute to cognitive performance deficits that may endanger flight safety and increase the risk of accidents.
aimIn this study, we aimed to identify region-specific alterations in CBF in male pilots after exposure to hypoxia. MATERIAL AND
methodsWe used 3D pseudo-continuous arterial spin labeling sequences in 35 healthy male pilots (mean age: 30.6 ± 4.82 years) under simulated hypoxic conditions with a 3.0-T magnetic resonance imaging scanner. The generated CBF maps were measured and averaged in several regions of interest.
resultsHypoxia decreased CBF in various brain regions, including the right temporal and bilateral occipital lobes, the anterior and posterior lobes of the cerebellum, the culmen and declive, and the inferior semilunar lobule of the cerebellum.
conclusionThese changes may impact the functional activity of the brains of pilots experiencing hypoxia in flight, but the related mechanisms require further investigation.
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