ArticleCurrent topics in behavioral neurosciences2021
Childhood Maltreatment in Bipolar Disorders.
Article in Current topics in behavioral neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing.BMC medicine · 2026Article
- Dissociative Bipolar At-Risk Phenotype: Traumatic Burden and Subthreshold Affective Psychopathology in a Help-Seeking Youth Sample.Brain sciences · 2026Article
- Lurasidone response in bipolar type I depression with childhood trauma exposure.The international journal of neuropsychopharmacology · 2025Observational
- The effect of childhood trauma on bipolar depression.Scientific reports · 2025Article
- Childhood maltreatment influences coping in youths with major depression and bipolar depression through resilience and impulsivity.Scientific reports · 2025Article
- The role of interpersonal trauma and substance use in mental health: A large population-based study.Psychiatry research · 2024Article
- Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders.Scientific reports · 2023Article
- Risk of childhood trauma exposure and severity of bipolar disorder in Colombia.International journal of bipolar disorders · 2023Article
- The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress.Neuropsychiatric disease and treatment · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this chapter, we will focus on childhood maltreatment and its role in the vulnerability to BD.We will review how childhood maltreatment and trauma not only predispose to the development of BD but also to a more unstable, pernicious, and severe clinical expression of the disorder. This environmental risk factor is suggested to be part of a multiple hit model of vulnerability, involving not only early stressors (prenatal and postnatal ones) but also interactions with the genetic background of individuals and with other stressors occurring later in life. We will also review how childhood maltreatment and trauma may modify the brain functioning and circuits and alter some biological pathways in BD, hence leading to psychopathology. Finally, we will briefly discuss the implications for clinical practice and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.