Evidence map›Paper›PMID 32653948›Full record

ArticleArchives of gynecology and obstetrics2020

Glycosylated fibronectin as a first trimester marker for gestational diabetes.

Julia Alanen, Heidi Appelblom, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Mika Gissler, Markku Ryynanen, Jaana Nevalainen

Open access · hybridAbstract read
In one paragraph

Article in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  6. Article
  7. First Trimester Placental Biomarkers for Pregnancy Outcomes.International journal of molecular sciences · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Julia AlanenDepartment of Obstetrics and Gynecology, Medical Research Center, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, PL 24, 90100 OYS, Oulu, Finland.
Heidi AppelblomPerkinElmer, Turku, Finland.
Teemu KorpimakiPerkinElmer, Turku, Finland.
Heikki KouruPerkinElmer, Turku, Finland.
Mikko SairanenPerkinElmer, Turku, Finland.
Mika GisslerNational Institute for Health and Welfare, Helsinki, Finland.
Markku RyynanenDepartment of Obstetrics and Gynecology, Medical Research Center, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, PL 24, 90100 OYS, Oulu, Finland.
Jaana NevalainenDepartment of Obstetrics and Gynecology, Medical Research Center, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, PL 24, 90100 OYS, Oulu, Finland. marttjaa@paju.oulu.fi.ORCID 0000-0001-9720-9676
PerkinElmer (Finland) · FIOulu University Hospital · FIFinnish Institute for Health and Welfare · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the performance of first trimester maternal serum glycosylated (Sambucus nigra lectin-reactive) fibronectin in prediction of gestational diabetes mellitus (GDM).

methodsIn this case-control study, first trimester maternal serum glycosylated fibronectin and fibronectin were measured in 19 women who consequently developed GDM and in 59 control women with normal pregnancy outcomes. Adiponectin was used as a reference protein to evaluate relation of glycoprotein to SNA-lectin-reactive assay format. Samples were taken during gestational weeks 9

resultsThere was no difference in maternal serum glycosylated fibronectin concentrations between women with consequent GDM [447.5 μg/mL, interquartile range (IQR) 254.4-540.9 μg/mL] and control women (437.6 μg/mL, IQR 357.1-569.1 μg/mL). Maternal serum fibronectin levels were significantly lower in GDM group (224.2 μg/mL, IQR 156.8-270.6 μg/mL), compared to the control group (264.8 μg/mL, IQR 224.6-330.6 μg/mL, p < 0.01). There was no difference in assay formats for adiponectin.

conclusionThere was no association between first trimester maternal serum glycosylated (SNA-reactive) fibronectin and GDM.

Indexed as

AdiponectinAdultBiomarkersCase-Control StudiesDiabetes, GestationalFemaleFibronectinsFinlandGlycated ProteinsGlycation End Products, AdvancedHumansMaternal Serum Screening TestsPregnancyPregnancy OutcomePregnancy Trimester, FirstRetrospective StudiesAdiponectinBiomarkersFibronectinsFN1 protein, humanglycated fibronectinGlycated ProteinsGlycation End Products, AdvancedBiomarkerFibronectinFirst trimester screeningGestational diabetes

Identifiers

PMID32653948
PMCPMC7471182
OpenAlexW3041649229

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.