Evidence map›Paper›PMID 32653906›Full record

ArticleJournal of tropical pediatrics2021

Guillain-Barré Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient.

Carlos Henrique Michiles Frank, Taynná Vernalha Rocha Almeida, Elyana Almeida Marques, Quezia de Sousa Monteiro, Pablo Vinícius Silveira Feitoza, Mayla Gabriela Silva Borba, Heline Lira Vasconcelos, Michele de Souza Bastos, Marcus Vinicius Guimarães Lacerda

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 8 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 8 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  9. Review
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  17. Post‑COVID‑19 syndrome in children (Review).Experimental and therapeutic medicine · 2022
    Review
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  19. Guillain-Barre syndrome following subclinical COVID-19 infection in a child.Journal of family medicine and primary care · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Carlos Henrique Michiles FrankFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, 69040-000 Brazil.
Taynná Vernalha Rocha AlmeidaPrograma de Pós-graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus, AM, 69080-900 Brazil.
Elyana Almeida MarquesFundação Alfredo da Mata, Manaus, AM, 69065-130 Brazil.
Quezia de Sousa MonteiroHospital e Pronto Socorro Delphina Rinaldi Abdel Aziz, Manaus, AM, 69093-415 Brazil.
Pablo Vinícius Silveira FeitozaDepartamento de Clínica Cirúrgica, Faculdade de Medicina, Universidade Federal do Amazonas, AM, 69080-900 Brazil.
Mayla Gabriela Silva BorbaHospital e Pronto Socorro Delphina Rinaldi Abdel Aziz, Manaus, AM, 69093-415 Brazil.
Heline Lira VasconcelosFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, 69040-000 Brazil.
Michele de Souza BastosFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, 69040-000 Brazil.
Marcus Vinicius Guimarães LacerdaInstituto Leonidas and Maria Deane, Fiocruz Amazonas, Manaus, AM, 69057-070 Brazil.
Fundação de Medicina Tropical · BRUniversidade de São Paulo · BRUniversidade do Estado do Amazonas · BRUniversidade Federal do Amazonas · BR

Funding

Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM), Programa Primeiros Projetos/Conselho Nacional de Desenvolvimento Científico e Tecnológico-Edital 06201105/2017
6 · The paper itself

Abstract

We report the case of a 15-year-old male patient presenting frontal headaches with retro-orbital pain accompanied by fever evolving to weakness and pain of the lower limbs, which ascended to upper limbs. A COVID-19 rapid test (IgG and IgM) and nasopharyngeal swab polymerase chain reaction (PCR) was positive for SARS-CoV-2. The blood tests, cerebral spinal fluid (CSF) analysis and CSF aerobic culture revealed no abnormalities. PCR testing of the CSF was negative for the most prevalent etiologies as well as for SARS-CoV-2. Electroneurography study was compatible with the acute motor axonal neuropathy variant of Guillain-Barré syndrome. No cases involving young patients have been presented to date. Therefore, this is the first reported pediatric case of SARS-CoV-2 infection associated with GBS. Evidence reveals that SARS-CoV-2 infection is not limited to the respiratory tract. Neurotropism could explain this important neurologic manifestation of COVID-19 in children.

Indexed as

COVID-19Guillain-Barre SyndromeAdolescentChildHeadacheHumansMalePainSARS-CoV-2adolescentGuillain–Barréneuromuscular diseasespediatricsSARS-CoV-2syndrome

Identifiers

PMID32653906
PMCPMC7529009
OpenAlexW3041568858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.