ReviewExperimental eye research2020
Biology of keratorefractive surgery- PRK, PTK, LASIK, SMILE, inlays and other refractive procedures.
Review in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pooled it
- Efficacy of single-step transepithelial photorefractive keratectomy in myopia, hyperopia and astigmatism-a systematic review.BMC ophthalmology · 2025Pooled it
- Efficacy of gabapentin and pregabalin for treatment of post refractive surgery pain: a systematic review and meta-analysis.International ophthalmology · 2024Pooled it
- Comparison of transepithelial and conventional photorefractive keratectomy in myopic and myopic astigmatism patients: a randomized contralateral trial.BMC ophthalmology · 2022Trial
- Stromal mechanical anisotropy of the SMILE lenticule shows no detectable association with postoperative refractive error.BMC ophthalmology · 2026Article
- Higher order aberrations and visual quality after refractive surgeries for myopia: a systematic review and network meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- CLEAR Lenticule Extraction for Enhancement After Primary Lenticule Extraction Surgery.Journal of clinical medicine · 2026Article
- Management after two consecutive suction losses during small-incision lenticule extraction: A case report.Experimental and therapeutic medicine · 2026Article
- Preoperative and postoperative risk factors for persistent dry eye after corneal refractive surgery in ultra-high myopia: a retrospective cohort study.American journal of translational research · 2026Article
- Refractive outcome and visual quality of Ray-Tracing Guided LASIK: a prospective study.BMC ophthalmology · 2025Observational
- Non-traumatic bilateral corneal flap dislocation 20 years after LASIK.BMC ophthalmology · 2025Article
- Clinical analysis of dry eye after refractive surgery in army recruits in 2024.Scientific reports · 2025Article
- Transepithelial Versus Conventional PRK: A Randomized Controlled Study.Ophthalmology and therapy · 2025Article
- Long-term refractive outcomes and corneal remodeling after the SMILE surgery in patients with moderate to extra-high myopia.BMC ophthalmology · 2025Article
- Impact of corneal curvature on 2-year postoperative visual outcomes after small incision lenticule extraction for high myopia.International ophthalmology · 2025Article
- Clinical effect and prognosis of laparoscopic surgery on colon cancer complicated with intestinal obstruction patients.World journal of gastrointestinal surgery · 2025Article
- The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery.Scientific reports · 2025Article
- Article
- Multifunctional Mesoporous Titanium Dioxide Nanodrug for Corneal Haze Treatment and Its Mechanism.Biomaterials research · 2025Article
- Based on TransRes-Pix2Pix network to generate the OBL image during SMILE surgery.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The outcomes of refractive surgical procedures to improve uncorrected vision in patients-including photorefractive keratectomy (PRK), laser in-situ keratomileusis (LASIK), Small Incision Lenticule Extraction (SMILE) and corneal inlay procedures-is in large part determined by the corneal wound healing response after surgery. The wound healing response varies depending on the type of surgery, the level of intended correction of refractive error, the post-operative inflammatory response, generation of opacity producing myofibroblasts and likely poorly understood genetic factors. This article details what is known about these specific wound healing responses that include apoptosis of keratocytes and myofibroblasts, mitosis of corneal fibroblasts and myofibroblast precursors, the development of myofibroblasts from keratocyte-derived corneal fibroblasts and bone marrow-derived fibrocytes, deposition of disordered extracellular matrix by corneal fibroblasts and myofibroblasts, healing of the epithelial injury, and regeneration of the epithelial basement membrane. Problems with epithelial and stromal cellular viability and function that are altered by corneal inlays are also discussed. A better understanding of the wound healing response in refractive surgical procedures is likely to lead to better treatments to improve outcomes, limit complications of keratorefractive surgical procedures, and improve the safety and efficiency of refractive surgical procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.