ReviewPaediatric respiratory reviews2020
Rational use of mucoactive medications to treat pediatric airway disease.
Review in Paediatric respiratory reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Use of dornase alfa in the paediatric intensive care unit: current literature and a national cross-sectional survey.European journal of hospital pharmacy : science and practice · 2022Pooled it
- Expert opinion and clinical practice recommendations using a modified Delphi approach for pediatric acute cough evaluation and management in India.Lung India : official organ of Indian Chest Society · 2026Article
- Association of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution with Respiratory Symptom Improvement and Safety in Chinese Children with Pneumonia: A Real-World Propensity Score-Matched Study.Infection and drug resistance · 2026Article
- Patterns of Use of β-2 Agonists, Steroids, and Mucoactive Medications to Treat Bronchiolitis in the PICU: U.S. Pediatric Health Information System 2009-2022 Database Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.Drugs in context · 2025Review
- Effectiveness of mechanical vibration-assisted sputum clearance in pediatric pneumonia: a randomized controlled trial with development of an intelligent parameter optimization model.Frontiers in pediatrics · 2025Article
- Severe respiratory syncytial virus disease.Journal of intensive medicine · 2024Review
- Therapeutic Management of Bronchiectasis in Children and Adolescents: A Concise Narrative Review.Journal of clinical medicine · 2024Review
- Prevention and Treatment Strategies for Respiratory Syncytial Virus (RSV).Pathogens (Basel, Switzerland) · 2023Review
- Expert group recommendation on inhaled mucoactive drugs in pediatric respiratory diseases: an Indian perspective.Frontiers in pediatrics · 2023Review
- Nanoparticle-Based Inhalation Therapy for Pulmonary Diseases.Current drug metabolism · 2022Article
- Everything That Wheezes Is Not Asthma: A Case Report.Pediatric allergy, immunology, and pulmonology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many airway diseases in children, notably bronchiolitis, cystic fibrosis (CF), non-CF bronchiectasis including primary ciliary dyskinesia, pneumonia, and severe asthma are associated with retention of airway secretions. Medications to improve secretions clearance, the mucoactive medications, are employed to treat these diseases with varying degrees of success. This manuscript reviews evidence for the use of these medications and future directions of study.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.