Evidence map›Paper›PMID 32653449›Full record

ArticleJACC. Heart failure2020

Hemodynamic and Functional Impact of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction.

Katlyn E Koepp, Masaru Obokata, Yogesh N V Reddy, Thomas P Olson, Barry A Borlaug

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 4 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 4 syntheses or guidelines pooled it, 250 citations in OpenAlex.

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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katlyn E KoeppDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Masaru ObokataDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Yogesh N V ReddyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Thomas P OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: borlaug.barry@mayo.edu.
Mayo Clinic · USWinnMed · US

Funding

Mayo Heart Failure Regional Clinical CenterU10HL110262 · NHLBI · MAYO CLINIC ROCHESTER · PI REDFIELD, MARGARET M · 2012 to 2018
$3.6M
Peripheral Mechanisms of Cardiopulmonary Control during ExerciseR01HL126638 · NHLBI · MAYO CLINIC ROCHESTER · PI OLSON, THOMAS PATRICK · 2015 to 2019
$2.9M
HL-Inorganic Nitrite to Enhance Benefits from Exercise Training in Heart Failure with preserved Ejection FractionR01HL128526 · NHLBI · MAYO CLINIC ROCHESTER · PI BORLAUG, BARRY A. · 2016 to 2019
$2.4M
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).U01HL125205 · NHLBI · MAYO CLINIC ROCHESTER · PI FRANTZ, ROBERT PAUL · 2014 to 2018
$1.5M
Visceral Adipose Tissue and Exercise Capacity in Heart Failure with preserved Ejection FractionF31HL143952 · NHLBI · UNIVERSITY OF MINNESOTA · PI BORLAUG, KATLYN ELIZABETH KOEPP · 2018 to 2020
$122k
NHLBI NIH HHS F31 HL143952NHLBI NIH HHS R01 HL126638NHLBI NIH HHS R01 HL128526NHLBI NIH HHS U01 HL125205NHLBI NIH HHS U10 HL110262
6 · The paper itself

Abstract

objectivesThis study determined the impact of excess epicardial adipose tissue (EAT) in patients with the obese phenotype of heart failure with preserved ejection fraction (HFpEF).

backgroundPatients with HFpEF and an elevated body mass index differ from nonobese patients, but beyond generalized obesity, fat distribution may be more important. Increases in EAT are associated with excess visceral adiposity, inflammation, and cardiac fibrosis, and EAT has been speculated to play an important role in the pathophysiology of HFpEF, but no study has directly evaluated this question.

methodsPatients with HFpEF and obesity (n = 169) underwent invasive hemodynamic exercise testing with expired gas analysis and echocardiography. Increased EAT was defined by echocardiography (EAT thickness ≥9 mm).

resultsCompared with obese patients without increased EAT (HFpEF

conclusionsAmong patients with the obese phenotype of HFpEF, the presence of increased EAT is associated with more profound hemodynamic derangements at rest and exercise, including greater elevation in cardiac filling pressures, more severe pulmonary hypertension, and greater pericardial restraint, culminating in poorer exercise capacity. Further study is needed to understand the biology and treatment of excessive EAT in patients with HFpEF.

Indexed as

Adipose TissueAgedEchocardiographyExercise ToleranceFemaleFollow-Up StudiesHeart AtriaHeart FailureHeart VentriclesHumansMalePericardiumPulmonary Wedge PressureRetrospective StudiesStroke Volumeepicardial fatheart failurehemodynamicsHFpEFobesitypericardiumpulmonary hypertension

Identifiers

PMID32653449
PMCPMC7395878
OpenAlexW3041438146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.