ArticleThe Journal of thoracic and cardiovascular surgery2021
Use of patient-specific computational models for optimization of aortic insufficiency after implantation of left ventricular assist device.
Article in The Journal of thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Artificial intelligence in computational modeling of thrombosis: Bridging mechanistic insights and clinical translation.Journal of thrombosis and thrombolysis · 2026Pooled it
- A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.Biomechanics and modeling in mechanobiology · 2026Article
- Heart transplantation following a successful bridge-to-bridge strategy in acute type A aortic dissection with left main coronary malperfusion.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Use of in silico research in the development of abdominal and thoracic surgical devices: a systematic review.BMJ innovations · 2025Article
- Management of aortic valve insufficiency in patients with continuous-flow left ventricular assist device: a republication of the review published in Japanese Journal of Artificial Organs.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Review
- Enhancing the implantation of mechanical circulatory support devices using computational simulations.Frontiers in bioengineering and biotechnology · 2024Article
- Transcatheter aortic valve replacement in the management of aortic insufficiency secondary to left ventricular assist device implantation: a case report.Journal of thoracic disease · 2023Article
- The Impact of Left Ventricular Assist Device Outflow Graft Positioning on Aortic Hemodynamics: Improving Flow Dynamics to Mitigate Aortic Insufficiency.Biomimetics (Basel, Switzerland) · 2023Article
- Assessment of valve implantation in the descending aorta as an alternative for aortic regurgitation patients not treatable with conventional procedures.Biomechanics and modeling in mechanobiology · 2023Article
- svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies.Journal of biomechanical engineering · 2023Article
- Aortic valve disorders and left ventricular assist devices.Frontiers in cardiovascular medicine · 2023Review
- The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD.Frontiers in cardiovascular medicine · 2023Review
- Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.Medical & biological engineering & computing · 2022Article
- Concomitant or late aortic valve intervention and its efficacy for aortic insufficiency associated with continuous-flow left ventricular assist device implantation.Frontiers in cardiovascular medicine · 2022Review
- Prediction, prevention, and management of right ventricular failure after left ventricular assist device implantation: A comprehensive review.Frontiers in cardiovascular medicine · 2022Review
- Pathophysiology and management of valvular disease in patients with destination left ventricular assist devices.Frontiers in cardiovascular medicine · 2022Review
- Patient-Specific Computational Fluid Dynamics Reveal Localized Flow Patterns Predictive of Post-Left Ventricular Assist Device Aortic Incompetence.Circulation. Heart failure · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAortic incompetence (AI) is observed to be accelerated in the continuous-flow left ventricular assist device (LVAD) population and is related to increased mortality. Using computational fluid dynamics (CFD), we investigated the hemodynamic conditions related to the orientation of the LVAD outflow in these patients.
methodWe identified 10 patients with new aortic regurgitation, and 20 who did not, after LVAD implantation between 2009 and 2018. Three-dimensional models of patients' aortas were created from their computed tomography scans. The geometry of the LVAD outflow graft in relation to the aorta was quantified using azimuth angles (AA), polar angles (PAs), and distance from aortic root. The models were used to run CFD simulations, which calculated the pressures and wall shear stress (rWSS) exerted on the aortic root.
resultsThe AA and PA were found to be similar. However, for combinations of high values of AA and low values of PA, there were no patients with AI. The distance from aortic root to the outflow graft was also smaller in patients who developed AI (3.39 ± 0.7 vs 4.07 ± 0.77 cm, P = .04). There was no significant difference in aortic root pressures in the 2 groups. The rWSS was greater in AI patients (4.60 ± 5.70 vs 2.37 ± 1.20 dyne/cm
conclusionsUsing CFD simulations, we demonstrated that patients who developed de novo AI have greater rWSS at the aortic root, and their outflow grafts were placed closer to the aortic roots than those patients without de novo AI.
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