ArticleMicrobial cell factories2020
The influence of transketolase on lipid biosynthesis in the yeast Yarrowia lipolytica.
Article in Microbial cell factories, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring the Regulatory Mechanism of Sodium Butyrate on Milk Fat Synthesis in Lactating Goats Fed a High-Concentrate Diet Based on Metabolomics Technology.Physiological research · 2026Article
- Enzyme-constrained genome-scale model of Yarrowia lipolytica predicts growth-phase specific metabolic engineering targets.Applied microbiology and biotechnology · 2026Article
- Regulating Glycerol Metabolism to Investigate the Effects of EngineeredFoods (Basel, Switzerland) · 2026Article
- Tropical lakes as a novel source of oleaginous yeasts with lipid profiles for biodiesel, oleochemical, and nutraceutical applications.World journal of microbiology & biotechnology · 2025Article
- Model-Driven Engineering of Yarrowia lipolytica for Improved Microbial Oil Production.Microbial biotechnology · 2025Article
- Engineering Yarrowia lipolytica for the production of β-carotene by carbon and redox rebalancing.Journal of biological engineering · 2025Article
- Metabolomics Reveals the Mechanism by Which Sodium Butyrate Promotes the Liver Pentose Phosphate Pathway and Fatty Acid Synthesis in Lactating Goats.Animals : an open access journal from MDPI · 2024Article
- Protein rational design and modification of erythrose reductase for the improvement of erythritol production in Yarrowia lipolytica.Bioprocess and biosystems engineering · 2024Article
- Mutation in yl-HOG1 represses the filament-to-yeast transition in the dimorphic yeast Yarrowia lipolytica.Microbial cell factories · 2023Article
- In-depth analysis of erythrose reductase homologs in Yarrowia lipolytica.Scientific reports · 2023Article
- Identification of Mycoparasitism-Related Genes against the PhytopathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Elevating Phospholipids ProductionInternational journal of molecular sciences · 2022Article
- Brown seaweed hydrolysate as a promising growth substrate for biomass and lipid synthesis of the yeastFrontiers in bioengineering and biotechnology · 2022Article
- Metabolic Engineering for Unusual Lipid Production inMicroorganisms · 2020Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDuring the pentose phosphate pathway (PPP), two important components, NADPH and pentoses, are provided to the cell. Previously it was shown that this metabolic pathway is a source of reducing agent for lipid synthesis from glucose in the yeast Yarrowia lipolytica. Y. lipolytica is an attractive microbial host since it is able to convert untypical feedstocks, such as glycerol, into oils, which subsequently can be transesterified to biodiesel. However, the lipogenesis process is a complex phenomenon, and it still remains unknown which genes from the PPP are involved in lipid synthesis.
resultsTo address this problem we overexpressed five genes from this metabolic pathway: transaldolase (TAL1, YALI0F15587g), transketolase (TKL1, YALI0E06479g), ribulose-phosphate 3-epimerase (RPE1, YALI0C11880g) and two dehydrogenases, NADP
conclusionsSimultaneous overexpression of DGA1 and TKL1 genes results in a higher lipid titer independently from the fermentation conditions, such as carbon source, pH and YE supplementation.
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