ArticleRadiation oncology (London, England)2020
Exploring MR regression patterns in rectal cancer during neoadjuvant radiochemotherapy with daily T2- and diffusion-weighted MRI.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Apparent diffusion coefficient increases during short course radiotherapy in rectal tumours: Results from a multicentre longitudinal trial.Physics and imaging in radiation oncology · 2025Article
- Early response prediction during radiotherapy in rectal cancer using sequential diffusion-weighted imaging at a magnetic resonance image-guided linear accelerator.Physics and imaging in radiation oncology · 2025Article
- Quantitative Method for Monitoring Tumor Evolution During and After Therapy.Journal of personalized medicine · 2025Article
- MRI navigation surgery for T4b rectal cancer using multiple minimally invasive surgical approaches.International journal of colorectal disease · 2025Article
- Forecasting Individual Patients' Best Time for Surgery in Colon-Rectal Cancer by Tumor Regression during and after Neoadjuvant Radiochemotherapy.Journal of personalized medicine · 2023Article
- Functional information guided adaptive radiation therapy.Frontiers in oncology · 2023Article
- Article
- T2 relaxation time for the early prediction of treatment response to chemoradiation in locally advanced rectal cancer.Insights into imaging · 2022Article
- Tumor Volume Regression during and after Radiochemotherapy: A Macroscopic Description.Journal of personalized medicine · 2022Article
- T2*-weighted imaging and diffusion kurtosis imaging (DKI) of rectal cancer: correlation with clinical histopathologic prognostic factors.Abdominal radiology (New York) · 2022Article
- Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians.CA: a cancer journal for clinicians · 2022Review
- Quantitative Magnetic Resonance Imaging for Biological Image-Guided Adaptive Radiotherapy.Frontiers in oncology · 2020Review
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12 authors at 5 institutions in 1 country.
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Abstract
backgroundTo date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive radiotherapy (RT) concepts. This exploratory study prospectively evaluated daily fractional MRI during neoadjuvant treatment to analyze the predictive value of MR biomarkers for treatment response.
methodsLocally advanced rectal cancer patients were examined with daily MRI during neoadjuvant RCT. Contouring of the tumor volume was performed for each MRI scan by using T2- and diffusion-weighted-imaging (DWI)-sequences. The daily apparent-diffusion coefficient (ADC) was calculated. Volumetric and functional tumor changes during RCT were analyzed and correlated with the pathological response after surgical resection.
resultsIn total, 171 MRI scans of eight patients were analyzed regarding anatomical and functional dynamics during RCT. Pathological complete response (pCR) could be achieved in four patients, and four patients had a pathological partial response (pPR) following neoadjuvant treatment. T2- and DWI-based volumetry proved to be statistically significant in terms of therapeutic response, and volumetric thresholds at week two and week four during RCT were defined for the prediction of pCR. In contrast, the average tumor ADC values widely overlapped between both response groups during RCT and appeared inadequate to predict treatment response in our patient cohort.
conclusionThis prospective exploratory study supports the hypothesis that MRI may be able to predict pCR of rectal cancers early during neoadjuvant RCT. Our data therefore provide a useful template to tailor future MR-guided adaptive treatment concepts.
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