SynthesisBMC oral health2020
Epidemiologic relationship between periodontitis and type 2 diabetes mellitus.
Synthesis in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
227 citing papers in PubMed, 9 syntheses or guidelines pooled it, 379 citations in OpenAlex.
- Grading the evidence for the association between periodontal disease and chronic non-communicable diseases: an umbrella review of meta-analyses of observational studies.BMC oral health · 2026Pooled it
- Efficacy of nonsurgical periodontal treatment on patients with periodontitis and type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis.Acta odontologica Scandinavica · 2025Pooled it
- Prevalence of xerostomia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- Motivational Interviewing on Periodontal Treatment Outcomes: A Meta-Analysis.International dental journal · 2024Pooled it
- Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Periodontal Disease and Alzheimer's: Insights from a Systematic Literature Network Analysis.The journal of prevention of Alzheimer's disease · 2024Pooled it
- The effects of aerobic exercise on 24-hour mean blood glucose levels measured by continuous glucose monitoring in type 2 diabetes: a meta-analysis.Frontiers in physiology · 2024Pooled it
- Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis.BMC endocrine disorders · 2022Pooled it
- Effects of Mobile-Based AI-Enhanced Health Counseling on Protection Motivation, Self-Care Behaviors, and Periodontal Treatment Outcomes in Patients With Periodontitis: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Trial
- Epithelial Inflammatory iNOS-Nitrate Axis EnhancesInternational journal of molecular sciences · 2026Article
- Research Trends in Antimicrobial Oral Hygiene Products, the Oral Microbiome, and Dental Biofilm: A Bibliometric Analysis (2006-2025).Antibiotics (Basel, Switzerland) · 2026Article
- Delivery of Dietary Advice for Type 2 Diabetes in Dental Settings and Its Relevance to Dental Practitioners: A Scoping Review.Health science reports · 2026Review
- Healing Response to Hyaluronic Acid Supplemented with Selected Amino Acids: A Pooled Analysis of Two Clinical Studies.Journal of functional biomaterials · 2026Article
- Diabetes Mellitus and Endo-Periodontal Lesions: An HbA1c-Guided Framework for Clinical Decision-Making.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Article
- Periodontitis and diabetes: a bidirectional link.Acta diabetologica · 2026Review
- Article
167 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTo systematically review the epidemiologic relationship between periodontitis and type 2 diabetes mellitus (T2DM).
methodsFour electronic databases were searched up until December 2018. The manual search included the reference lists of the included studies and relevant journals. Observational studies evaluating the relationship between T2DM and periodontitis were included. Meta-analyses were conducted using STATA.
resultsA total of 53 observational studies were included. The Adjusted T2DM prevalence was significantly higher in periodontitis patients (OR = 4.04, p = 0.000), and vice versa (OR = 1.58, p = 0.000). T2DM patients had significantly worse periodontal status, as reflected in a 0.61 mm deeper periodontal pocket, a 0.89 mm higher attachment loss and approximately 2 more lost teeth (all p = 0.000), than those without T2DM. The results of the cohort studies found that T2DM could elevate the risk of developing periodontitis by 34% (p = 0.002). The glycemic control of T2DM patients might result in different periodontitis outcomes. Severe periodontitis increased the incidence of T2DM by 53% (p = 0.000), and this result was stable. In contrast, the impact of mild periodontitis on T2DM incidence (RR = 1.28, p = 0.007) was less robust.
conclusionsThere is an evident bidirectional relationship between T2DM and periodontitis. Further well-designed cohort studies are needed to confirm this finding. Our results suggest that both dentists and physicians need to be aware of the strong connection between periodontitis and T2DM. Controlling these two diseases might help prevent each other's incidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.