ArticleBMC neurology2020
Detailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: unremarkable or not?
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Reversible cognitive and gait impairment by a giant quadrigeminal cistern arachnoid cyst: A case report of marked reversal following neuroendoscopic fenestration.Surgical neurology international · 2026Article
- Degenerative pathologies on cortical biopsy, dopaminergic depletion, and shunt efficacy in iNPH.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Hydrocephalus: Molecular and Neuroimaging Biomarkers in Diagnosis and Management.Biomedicines · 2025Review
- The eagle-wing finding in FP-CIT SPECT, as a characteristic finding in patients with DESH- type iNPH.Neuroradiology · 2025Article
- The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.Frontiers in neurology · 2025Review
- Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Patient With Parkinson's Disease-Compatible Findings on Dopamine Transporter Scans.Dementia and neurocognitive disorders · 2024Article
- Imaging Procedure and Clinical Studies of [Nuclear medicine and molecular imaging · 2024Review
- Effect of cerebrospinal fluid area mask correction onBMC medical imaging · 2023Article
- The investigation of the gait parameter alterations in response to levodopa therapy and tap test in patients with idiopathic normal pressure hydrocephalus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Update on the Cognitive Presentations of iNPH for Clinicians.Frontiers in neurology · 2022Review
- Olfactory Dysfunction, an Often Neglected Symptom of Hydrocephalus: Experience from a Case of Late-Onset Idiopathic Aqueductal Stenosis.Case reports in neurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT imaging of iNPH patients remains to be further elucidated.
methodsIn this preliminary study, 11 patients with iNPH in our hospital between March 2017 and February 2019 were finally enrolled. A diagnosis of iNPH was made according to the two established criteria. For visual analysis of DAT imaging, a striatum was divided into five domains. A semi-quantitative visual assessment was performed with a consensus between a nuclear medicine specialist and an experienced neurologist who were blinded to the clinical diagnosis.
resultsStriatal dopaminergic deficits were abnormal in 90.9% (10/11) of patients with iNPH. The degree of dopaminergic reduction was mild and heterogeneous. However, a tendency of preferential striatal DAT loss in the caudate nucleus (90.9%, 10/11) than in the putamen (72.7%, 8/11) was observed, whereas ventral portion (9.1%, 1/11) was relatively preserved.
conclusionStriatal dopaminergic depletion might be mild and heterogeneous in patients with iNPH. These dopaminergic deficits were more common in the caudate nucleus than in the putamen, suggesting a pattern different from other degenerative parkinsonian disorders.
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