Evidence map›Paper›PMID 32652957›Full record

ArticleBMC neurology2020

LSVT-BIG therapy in Parkinson's disease: physiological evidence for proprioceptive recalibration.

Manuel Peterka, Thorsten Odorfer, Michael Schwab, Jens Volkmann, Daniel Zeller

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06927362 (Effects of Lee Silverman Voice Treatment Big and Dual Task Training on Balance, Cognition and Functional Mobility in Older Adults With Cognitive Impairment.), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06927362 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Lee Silverman Voice Treatment Big and Dual Task Training on Balance, Cognition and Functional Mobility in Older Adults With Cognitive Impairment.

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled50ConditionsCognitive Impairment, Balance Changes, Cognition Disorders in Old Age, Functional MobilityArmsLee Silverman treatment big, Dual task training
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Neurobehavioral Effects of LSVTFrontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manuel PeterkaDepartment of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany. manuelpeterka@gmx.net.ORCID http://orcid.org/0000-0002-4618-9115
Thorsten OdorferDepartment of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
Michael SchwabStiftung Bürgerspital zum Hl. Geist, 97070, Würzburg, Germany.
Jens VolkmannDepartment of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
Daniel ZellerDepartment of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is growing evidence for proprioceptive dysfunction in patients with Parkinson's disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase of movement amplitudes in persons with PD (PwPD), has shown to be effective on motor symptoms. LSVT-BIG is conceptionally based on improving bradykinesia, in particular the decrement of repetitive movements, by proprioceptive recalibration.

objectiveTo assess proprioceptive impairment in PwPD as compared to matched controls and to probe potential recalibration effects of the LSVT-BIG therapy on proprioception.

methodsProprioceptive performance and fine motor skills were assessed in 30 PwPD and 15 matched controls. Measurements with significant impairment in PwPD were chosen as outcome parameters for a standardized 4 weeks amplitude-based training intervention (LSVT-BIG) in 11 PwPD. Proprioceptive performance served as primary outcome measure. Secondary outcome measures included the motor part of the MDS-UPDRS, the nine-hole-peg test, and a questionnaire on quality of life. Post-interventional assessments were conducted at weeks 4 and 8.

resultsCompared to the control group, PwPD showed significantly larger pointing errors. After 4 weeks of LSVT-BIG therapy and even more so after an additional 4 weeks of continued training, proprioceptive performance improved significantly. In addition, quality of life improved as indicated by a questionnaire.

conclusionLSVT-BIG training may achieve a recalibration of proprioceptive processing in PwPD. Our data indicates a probable physiological mechanism of a symptom-specific, amplitude-based behavioral intervention in PwPD.

Indexed as

Exercise TherapyAgedFemaleHumansMaleMiddle AgedParkinson DiseaseProprioceptionQuality of LifeAmplitudeLSVT-big therapyPointing errorProprioceptionTraining

Identifiers

PMID32652957
PMCPMC7353788

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.