Observational studyBMC cardiovascular disorders2020
The risk factors for calcification vary among the different sections of the lower extremity artery in patients with symptomatic peripheral arterial disease.
Observational study in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Association Between DOAC Exposure and Lower-Extremity Arterial Calcification: A Propensity-Matched Exploratory CT Study.Journal of clinical medicine · 2026Article
- The predictive value of AGEF score for contrast-induced nephropathy in patients with lower extremity peripheral artery disease.BMC cardiovascular disorders · 2025Article
- Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Clinical Utility of Infrapopliteal Calcium Score for the Evaluation of Severity of Peripheral Artery Disease.Journal of vascular and interventional radiology : JVIR · 2024Article
- Lower limb arterial calcification and its clinical relevance with peripheral arterial disease.Frontiers in cardiovascular medicine · 2023Review
- Impact of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors on Arterial Stiffness and Vascular Aging-What Do We Know So Far? (A Narrative Review).Life (Basel, Switzerland) · 2022Review
- Explore the Value of Dual Source Computer Tomography Automatic Tube Current Regulation in Reducing the Radiation Dose of CTA in Lower Extremity Vessels.Frontiers in surgery · 2022Article
- Association of Plasma Bilirubin Levels With Peripheral Arterial Disease in Chinese Hypertensive Patients: New Insight on Sex Differences.Frontiers in physiology · 2022Article
- Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Successful Peripheral Vascular Intervention in Patients with High-risk Comorbidities or Lesion Characteristics.Current cardiology reports · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPeripheral arterial disease (PAD) is associated with considerable mortality and morbidity worldwide. The present study explored the risk factors for arterial calcification among the different sections of the lower extremity in patients with PAD and analyzed their correlations with the extent of arterial stenosis at the corresponding section.
methodsThis study enrolled symptomatic PAD patients from our hospital from March 2017 to March 2018. The lower extremity arterial calcification score (LEACS) and lower extremity arterial stenosis index (LEASI), representing the extent of arterial stenosis, were measured on computed tomography (CT) and the correlations between them were analyzed using Spearman's correlation analysis. The relationships between risk factors and calcification were analyzed among the different sections of the lower extremity artery.
resultsIn total, 209 patients were included. The LEACSs of the total lower extremity, aortoiliac artery, and femoropopliteal and infrapopliteal arteries were correlated with the LEASI (all P < 0.05), but their correlation was relatively weak in the aortoiliac artery. Univariate analysis showed that hypertension was associated with the total (P = 0.019) and aortoiliac (P = 0.012) LEACSs. Diabetes was related to both femoropopliteal (P = 0.001) and infrapopliteal (P = 0.002) LEACSs. The infrapopliteal LEACS was higher in male patients (P = 0.011). After adjustment for age, the above relationships were maintained among the different sections, but not in the total lower extremity artery.
conclusionsThe LEACS is associated with the LEASI in all arterial sections, but that of the aortoiliac artery was relatively weak. Different factors have different effects on calcification among the various sections of the lower extremity artery.
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