Evidence map›Paper›PMID 32652943›Full record

ArticleBMC nephrology2020

Healthy adult vegetarians have better renal function than matched omnivores: a cross-sectional study in China.

Kaijie Xu, Xueying Cui, Bian Wang, Qingya Tang, Jianfang Cai, Xiuhua Shen

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Effects of dietary interventions for metabolic acidosis in chronic kidney disease: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
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  7. Nutritional and Dietary Management of Chronic Kidney Disease Under Conservative and Preservative Kidney Care Without Dialysis.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kaijie XuDepartment of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.
Xueying CuiDepartment of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China.
Bian WangDepartment of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China.
Qingya TangDepartment of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.
Jianfang CaiDepartment of Nephrology, 4 Clinical Epidemiology Unit, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xiuhua ShenDepartment of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China. srachel@126.com.ORCID 0000-0001-8734-5041
Shanghai Jiao Tong University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Danone nutrition research and education fund DIC2016-07Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition 17DZ2272000
6 · The paper itself

Abstract

backgroundAn appropriate diet is an important determinant of kidney health. However, the association between vegetarian diets and renal function is unclear. We aimed to study the association between vegetarian diets and renal function in healthy adults.

methodsA total of 269 vegetarians and 269 sex- and age-matched nonvegetarian omnivores were enrolled in this cross-sectional study. Basic characteristics and daily dietary intakes were assessed by face-to-face interviews. Blood samples were collected, and renal function was assessed by measuring blood urea nitrogen (BUN), serum creatinine (SCr), uric acid (UA) and the estimated glomerular filtration rate (eGFR). Blood pressure, fasting blood glucose and blood lipid profiles were also assessed.

resultsThe average age of the vegetarians was 35.4 ± 8.6 years, 82.2% of whom were female. We evaluated the association between vegetarian diets and renal function using multivariate analysis. Compared with omnivores, vegetarians had lower BUN [β = - 0.63, 95% confidence interval (CI): (- 0.88, - 0.38)], SCr [β = - 2.04, 95% CI:(- 4.10, 0.02)], and UA levels [β = - 15.15, 95% CI: (- 27.81, - 2.50)] and higher eGFRs [β = 4.04, 95% CI: (0.30, 7.78)] after adjusting for sex, age, body mass index (BMI), physical activity, alcohol consumption, smoking status, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), systolic pressure and fasting blood glucose. Further analysis of food composition and renal function showed that dietary fiber intake was significantly negatively associated with BUN [β = - 0.02, 95% CI: (- 0.03, 0.00)], SCr [β = - 0.14, 95% CI: (- 0.25, 0.04)], and UA levels [β = - 0.72, 95% CI: (- 1.36, 0.07)] and positively associated with the eGFR [β = 0.20, 95% CI: (0.00, 0.40)].

conclusionsHealthy adult vegetarians have better renal function than omnivores, and the higher dietary fiber intake associated with vegetarian diets may contribute to the protective effect on renal function.

Indexed as

Dietary FiberDiet, VegetarianGlomerular Filtration RateAdultBlood PressureBlood Urea NitrogenChinaCholesterol, HDLCholesterol, LDLCreatinineCross-Sectional StudiesDietFemaleHumansMaleUric AcidCholesterol, HDLCholesterol, LDLCreatinineDietary FiberUric AcidDietary patternEstimated glomerular filtration rateKidneyRenal functionSerum creatinineUrea nitrogenUric acidVegetarian

Identifiers

PMID32652943
PMCPMC7353802
OpenAlexW3041590697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.