Evidence map›Paper›PMID 32652899›Full record

ArticlePhysiological reports2020

Muscle and serum myostatin expression in type 1 diabetes.

Athan G Dial, Cynthia M F Monaco, Grace K Grafham, Nadya Romanova, Jeremy A Simpson, Mark A Tarnopolsky, Christopher G R Perry, Evangelia Kalaitzoglou, Thomas J Hawke

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Athan G DialDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Cynthia M F MonacoDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Grace K GrafhamDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Nadya RomanovaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Jeremy A SimpsonDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Mark A TarnopolskyDeparment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Christopher G R PerrySchool of Kinesiology and Health Science, York University, Toronto, ON, Canada.
Evangelia KalaitzoglouBarnstable Brown Diabetes Center and Department of Pediatrics, University of Kentucky, Lexington, KY, USA.
Thomas J HawkeDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-4974-4820
McMaster University · CAUniversity of Guelph · CAUniversity of Kentucky · USYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle-wasting diseases, has not been reported in humans with T1D but has been demonstrated to be elevated in preclinical diabetes models. Thus, the purpose of this study was to determine if there is an elevated expression of myostatin in the serum and skeletal muscle of persons with T1D compared to controls. Secondarily, we aimed to explore relationships between myostatin expression and clinically important metrics (e.g., HbA

Indexed as

AdiposityAdolescentAdultAgedDiabetes Mellitus, Type 1FemaleHumansMaleMiddle AgedMuscle ContractionMuscle, SkeletalMyostatinSex FactorsMyostatinGDF-8myostatinskeletal muscleT1DTGF-family members

Identifiers

PMID32652899
PMCPMC7354085
OpenAlexW3041493832

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.