Evidence map›Paper›PMID 32652856›Full record

ArticleThe FEBS journal2020

A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention.

Stefan H Oehlers, Elinor Hortle, Kristina M Cook

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in The FEBS journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stefan H OehlersThe University of Sydney, Tuberculosis Research Program at the Centenary Institute, Camperdown, NSW, Australia.ORCID 0000-0003-0260-672X
Elinor HortleThe University of Sydney, Tuberculosis Research Program at the Centenary Institute, Camperdown, NSW, Australia.
Kristina M CookThe University of Sydney, Faculty of Medicine and Health & Charles Perkins Centre, Camperdown, NSW, Australia.ORCID 0000-0002-0503-7166
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.

Indexed as

Mycobacterium Infections, NontuberculousMycobacterium marinumTuberculosisAnimalsComorbidityDisease Models, AnimalHypoxia-Inducible Factor 1, alpha SubunitZebrafishHypoxia-Inducible Factor 1, alpha Subunithypoxiainflammationmycobacteriamycobacterialneutrophil

Identifiers

PMID32652856
OpenAlexW3042028874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.