ArticleIntegrative zoology2021
Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.
Article in Integrative zoology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Lemming population fluctuations around the Arctic.Proceedings. Biological sciences · 2024Article
- Geographic Variation in Organ Size in a Toad (Animals : an open access journal from MDPI · 2023Article
- Gut Microbiota is Associated with Aging-Related Processes of a Small Mammal Species under High-Density Crowding Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Effects of Group Size on Behavior, Reproduction, and mRNA Expression in Brains of Brandt's Voles.Brain sciences · 2023Article
- Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt's voles (Lasiopodomys brandtii).Microbiome · 2022Article
- Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.Frontiers in zoology · 2021Article
- Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021Review
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.Integrative zoology · 2021Article
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Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that social stress could alter oxytocin (OT) and arginine-vasopressin (AVP) expression in specific regions of brains which regulate the aggressive behavior of small rodents, but the effects of density-induced social stress are still unknown. Brandt's voles (Lasiopodomys brandtii) are small herbivores in the grassland of China, but the underlying neurological mechanism of population regulation is still unknown. We tested the effects of housing density of Brandt's voles on OT/AVP system with physical contact (allowing aggression) and without physical contact (not allowing aggression) under laboratory conditions. Then, we tested the effects of paired-aggression (no density effect) of Brandt's voles on OT/AVP system under laboratory conditions. We hypothesized that high density would increase aggression among animals which would then increase AVP but reduce OT in brains of animals. Our results showed that high housing density induced more aggressive behavior. We found high-density-induced social stress (with or without physical contact) and direct aggression significantly increased expression of mRNA and protein of AVP and its receptor, but decreased expression of mRNA and protein of OT and its receptor in specific brain regions of voles. The results suggest that density-dependent change of OT/AVP systems may play a significant role in the population regulation of small rodents by altering density-dependent aggressive behavior.
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