Evidence map›Paper›PMID 32652699›Full record

ArticleStatistics in medicine2020

Variable selection for high-dimensional partly linear additive Cox model with application to Alzheimer's disease.

Qiwei Wu, Hui Zhao, Liang Zhu, Jianguo Sun

Abstract read
In one paragraph

Article in Statistics in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Post-selection inference for the Cox model with interval-censored data.Scandinavian journal of statistics, theory and applications · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qiwei WuEli Lilly and Company, Indianapolis, Indiana, USA.
Hui ZhaoSchool of Statistics and Mathematics, Zhongnan University of Economics and Law, Wuhan, China.ORCID 0000-0002-5733-0102
Liang ZhuDivision of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0001-9815-0645
Jianguo SunDepartment of Statistics, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0002-6946-671X

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Innovative Statistical Analysis for Genome-Wide Data with Interval-Censored Outcomes of Oral Health in Childhood Cancer SurvivorsR03DE029238 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, YIMEI, SUN, RYAN · 2020 to 2021
$352k
NCATS NIH HHS UL1 TR003167NIA NIH HHS U01 AG024904NIDCR NIH HHS R03 DE029238
6 · The paper itself

Abstract

Variable selection has been discussed under many contexts and especially, a large literature has been established for the analysis of right-censored failure time data. In this article, we discuss an interval-censored failure time situation where there exist two sets of covariates with one being low-dimensional and having possible nonlinear effects and the other being high-dimensional. For the problem, we present a penalized estimation procedure for simultaneous variable selection and estimation, and in the method, Bernstein polynomials are used to approximate the involved nonlinear functions. Furthermore, for implementation, a coordinate-wise optimization algorithm, which can accommodate most commonly used penalty functions, is developed. A numerical study is performed for the evaluation of the proposed approach and suggests that it works well in practical situations. Finally the method is applied to an Alzheimer's disease study that motivated this investigation.

Indexed as

Alzheimer DiseaseAlgorithmsComputer SimulationHumansLinear ModelsProportional Hazards ModelsBernstein polynomialshigh-dimensional variable selectioninterval-censored datapartly linear additive Cox modelSieve estimation

Identifiers

PMID32652699
PMCPMC7936877

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.